Omega-3 consumption and sudden cardiac death in schizophrenia

Omega-3 consumption and sudden cardiac death in schizophrenia

Author Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cysneiros, Roberta M. Google Scholar
Terra, Vera C. Google Scholar
Scorza, Carla A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Ribeiro, Miriam O. Google Scholar
Gattaz, Wagner F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Presbiteriana Mackenzie
Universidade de São Paulo (USP)
Abstract People with schizophrenia show a two- to three-fold increased risk to die prematurely. Mortality is accounted for by a combination of factors (patients' life style, suicide, premature cardiovascular disease, metabolic syndromes and, not so often mentioned, sudden death). the cause of sudden death in schizophrenia is unknown, but cardiac arrhythmia plays a potential role. Patients with schizophrenia are at high risk for cardiovascular disease, and some antipsychotics may be associated with cardiovascular adverse events (e.g., electrocardiograph QT interval prolongation), suggesting that this could lead to sudden cardiac death. Animal and clinical studies have shown that omega-3 fatty acids could be useful in the prevention and treatment of schizophrenia. As omega-3 fatty acids have been considered a cardioprotector agent, reducing cardiac arrhythmias and hence sudden cardiac deaths and given their relative safety and general health benefits, our update article summarizes the knowledge by g the possible positive effects of omega-3 supplementation and fish consumption against sudden cardiac death in patients with schizophrenia. However, fish species should be selected with caution due to contamination with toxic methylmercury. (C) 2009 Elsevier B.V. All rights reserved.
Keywords Schizophrenia
Sudden cardiac death
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2009-10-01
Published in Prostaglandins Leukotrienes and Essential Fatty Acids. Oxford: Elsevier B.V., v. 81, n. 4, p. 241-245, 2009.
ISSN 0952-3278 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 241-245
Access rights Closed access
Type Review
Web of Science ID WOS:000271177300004

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