Prognostic factors and outcomes for osteosarcoma: An international collaboration

Show simple item record Pakos, Emilios E. Nearchou, Andreas D. Grimer, Robert J. Koumoullis, Haris D. Abudu, Adesegun Bramer, Jos A. M. Jeys, Lee M. Franchi, Alessandro Scoccianti, Guido Campanacci, Domenico Capanna, Rodolfio Aparicio, Jorge Tabone, Marie-Dominique Holzer, Gerold Abdolvahab, Fashid Funovics, Philipp Dominkus, Martin Ilhan, Inci Berrak, Su G. Patino-Garcia, Ana Sierrasesumaga, Luis San-Julian, Mikel Garraus, Moira Petrili, Antonio Sergio [UNIFESP] Garcia Filho, Reynaldo Jesus [UNIFESP] Pacheco Donato Macedo, Carla Renata [UNIFESP] Seixas Alves, Maria Teresa de [UNIFESP] Seiwerth, Sven Nagarajan, Rajaram Cripe, Timothy P. Ioannidis, John P. A. 2016-01-24T13:58:40Z 2016-01-24T13:58:40Z 2009-09-01
dc.identifier.citation European Journal of Cancer. Oxford: Elsevier B.V., v. 45, n. 13, p. 2367-2375, 2009.
dc.identifier.issn 0959-8049
dc.description.abstract We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. in multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. it was also influenced by the site of the tumour. the risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma. (C) 2009 Published by Elsevier B.V. en
dc.format.extent 2367-2375
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Cancer
dc.rights Acesso restrito
dc.subject Osteosarcoma en
dc.subject Clinical predictors en
dc.subject Prognosis en
dc.subject Survival en
dc.subject Metastasis en
dc.subject International collaboration en
dc.title Prognostic factors and outcomes for osteosarcoma: An international collaboration en
dc.type Artigo
dc.contributor.institution Univ Ioannina
dc.contributor.institution Royal Orthopaed Hosp
dc.contributor.institution Univ Florence
dc.contributor.institution Hosp Univ La Fe
dc.contributor.institution Hop Enfants Armand Trousseau
dc.contributor.institution Med Univ Vienna
dc.contributor.institution Ankara Oncol Hosp
dc.contributor.institution Marmara Univ
dc.contributor.institution Univ Navarra
dc.contributor.institution Univ Navarra Clin
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Med Fac Zagreb
dc.contributor.institution Cincinnati Childrens Hosp
dc.contributor.institution Tufts Univ
dc.description.affiliation Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Clin & Mol Epidemiol Unit, GR-45110 Ioannina, Greece
dc.description.affiliation Royal Orthopaed Hosp, Birmingham B31 2AP, W Midlands, England
dc.description.affiliation Univ Florence, Dept Human Pathol & Oncol, Florence, Italy
dc.description.affiliation Hosp Univ La Fe, Dept Med Oncol, Valencia, Spain
dc.description.affiliation Hop Enfants Armand Trousseau, Serv Hematooncol Pediat, Paris, France
dc.description.affiliation Med Univ Vienna, Dept Orthopaed, Vienna, Austria
dc.description.affiliation Ankara Oncol Hosp, Dept Pediat Oncol, Ankara, Turkey
dc.description.affiliation Marmara Univ, Med Ctr, Dept Pediat Hematol Oncol, Istanbul, Turkey
dc.description.affiliation Univ Navarra, Dept Pediat, E-31080 Pamplona, Spain
dc.description.affiliation Univ Navarra, Dept Orthoped, E-31080 Pamplona, Spain
dc.description.affiliation Univ Navarra Clin, Pamplona, Spain
dc.description.affiliation GRAACC UNIFESP, Inst Oncol Pediat, Pediat Oncol Sect, São Paulo, Brazil
dc.description.affiliation Med Fac Zagreb, Inst Pathol, Zagreb, Croatia
dc.description.affiliation Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA
dc.description.affiliation Tufts Univ, Sch Med, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies,Dept Med, Boston, MA 02111 USA
dc.description.affiliationUnifesp GRAACC UNIFESP, Inst Oncol Pediat, Pediat Oncol Sect, São Paulo, Brazil
dc.identifier.doi 10.1016/j.ejca.2009.03.005
dc.description.source Web of Science
dc.identifier.wos WOS:000270645700026


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