Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

Author Pompeia, Sabine Autor UNIFESP Google Scholar
Grego, Bruno H. C. Autor UNIFESP Google Scholar
Pradella-Hallinan, Marcia Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, could decrease homocysteine, and if changes were similar in both genders.Methods: This was a double-blind, cross-over design study of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n = 21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of flunitrazepam was reached). Various biochemical parameters were analysed, such as plasma homocysteine, cysteine, folate, vitamins B6, B12, and sexual hormones.Results: Flunitrazepam reduced cortisol (p = 0.0011), cysteine (p = 0.014) and homocysteine (p = 0.028) concentrations, irrespective of gender. No correlations were found between cortisol and other biochemical markers (all r's<0.03). Concentration of cysteine and homocysteine were negatively correlated with plasma flunitrazepam concentration, suggesting that changes in these amino acids might be related to the metabolism of this benzodiazepine.Conclusion: Acute administration of flunitrazepam decreases plasma homocysteine and cysteine by mechanisms that seem unrelated to changes in cortisol. Given the importance of homocysteine as a market of life-threatening disorders, the mechanisms involved in the decrease of these amino acids are potential targets for clinical application. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Benzodiazepine
Cortisol
Cysteine
Gender
Homocysteine
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
AFIP
Grant number FAPESP: 2005/03552-8
FAPESP: 2003/00046-9
FAPESP: 1998/14303-3
Date 2009-08-31
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 33, n. 6, p. 933-938, 2009.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 933-938
Origin http://dx.doi.org/10.1016/j.pnpbp.2009.04.017
Access rights Closed access
Type Review
Web of Science ID WOS:000269300600003
URI http://repositorio.unifesp.br/handle/11600/31750

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