Paradoxical Sleep Deprivation Influences Sexual Behavior in Female Rats

Paradoxical Sleep Deprivation Influences Sexual Behavior in Female Rats

Author Andersen, Monica L. Autor UNIFESP Google Scholar
Alvarenga, Tathiana A. F. Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Perry, Juliana C. Autor UNIFESP Google Scholar
Silva, Andressa Autor UNIFESP Google Scholar
Zager, Adriano Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction.Sleep disturbances are a frequent complaint in women and are often attributed to hormonal fluctuations during the menstrual cycle. Rodents have been used as models to examine the effects of sleep deprivation on hormonal and behavioral changes. Among the many comorbidities common to sleep disorders, sexual behavior remains the least well studied.Aim.To determine whether paradoxical sleep deprivation (PSD) can affect sexual receptivity (male acceptance) and proceptivity (male solicitation) behaviors in female rats.Methods.Female Wistar rats were subjected to PSD or were maintained as controls. After this period, the estrous cycle (proestrus, estrus, and diestrus) was determined, and all females were placed with a sexually experienced male. in order to investigate the role of hormones in sexual behavior, we included additional groups that were artificially induced to be sexually receptive via administration of a combination of estradiol and progesterone.Main Outcome Measurements.Receptivity and proceptivity behaviors, as well as progesterone and corticosterone concentrations were monitored.Results.Selective sleep loss caused a significant increase in proceptivity and receptivity behaviors in females exclusively during the proestrus phase. the rejection response was increased in PSD rats during the estrus and diestrus phases, as compared with PSD-receptive and proestrus females. PSD reduced progesterone levels during the proestrus phase relative to the respective control group during the same phase of the estrous cycle. the PSD-proestrus females that displayed the most robust sexual response exhibited greater concentrations of corticosterone than PSD-diestrus females, with an absence of sexual solicitation behaviors.Conclusions.PSD produced a distinct response in the hormonal profile that was consistent with the phase of the estrous cycle. These results show that sleep loss can affect sexual motivation and might lead to important clinical implications, including alterations in female physiology and reproductive abnormalities. Andersen ML, Alvarenga TAF, Guindalini C, Perry JC, Silva A, Zager A, and Tufik S. Paradoxical sleep deprivation influences sexual behavior in female rats. J Sex Med 2009;6:2162-2172.
Keywords Sleep
Sleep Deprivation
Sexual Behavior
Receptivity
Proceptivity
Progesterone
Cortisol
Corticosterone
Female Rats
Language English
Sponsor Associacao Fundo de Incentivo Psicofarmacologia (AFIP)
Fundacao de Amparo Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number Fundacao de Amparo Pesquisa do Estado de São Paulo: 98/14303-3
Fundacao de Amparo Pesquisa do Estado de São Paulo: 06/58274-5
Fundacao de Amparo Pesquisa do Estado de São Paulo: 07/56620-6
Fundacao de Amparo Pesquisa do Estado de São Paulo: 06/58275-1
CNPq: 558924/2008 5
Date 2009-08-01
Published in Journal of Sexual Medicine. Malden: Wiley-Blackwell Publishing, Inc, v. 6, n. 8, p. 2162-2172, 2009.
ISSN 1743-6095 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2162-2172
Origin http://dx.doi.org/10.1111/j.1743-6109.2009.01339.x
Access rights Closed access
Type Article
Web of Science ID WOS:000268466800011
URI http://repositorio.unifesp.br/handle/11600/31738

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