The V109G polymorphism in the p27 gene is associated with endometriosis

The V109G polymorphism in the p27 gene is associated with endometriosis

Author Camargo-Kosugi, Cintia M. Autor UNIFESP Google Scholar
Silva, Ismael D. C. G. da Autor UNIFESP Google Scholar
Sato, Helio Autor UNIFESP Google Scholar
D'Amora, Paulo Autor UNIFESP Google Scholar
Carvalho, Cristina V. Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara C. Autor UNIFESP Google Scholar
Girao, Manoel J. C. B. Autor UNIFESP Google Scholar
Schor, Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To investigate the prevalence of the p27 gene polymorphism in women with endometriosis.Study design: Transversal case-control study. Genomic DNA was extracted from cells collected from buccal swabs. the p27 V109G polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Brazilian population.Results: We analysed the 104 patients and 109 control subjects. the distribution of genotype and allele frequencies of p27 V109G polymorphism was significantly different between the endometriosis cases and healthy women (p = 0.016 and 0.002). Women who had at least one mutated allele presented twofold chances for endometriosis development (OR = 1.9; 95% Cl, 1.120-3.343).Conclusion: the polymorphic variant at codon 109 of the p27 gene seems to be associated with higher risk of endometriosis development. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Keywords Polymorphism
Endometriosis
p27
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06.58214-2
Date 2009-08-01
Published in European Journal of Obstetrics & Gynecology and Reproductive Biology. Clare: Elsevier B.V., v. 145, n. 2, p. 180-183, 2009.
ISSN 0301-2115 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 180-183
Origin http://dx.doi.org/10.1016/j.ejogrb.2009.04.027
Access rights Closed access
Type Article
Web of Science ID WOS:000268791600012
URI http://repositorio.unifesp.br/handle/11600/31716

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