Variation in the Distribution of Trace Elements in Renal Cell Carcinoma

Variation in the Distribution of Trace Elements in Renal Cell Carcinoma

Author Calvo, Fernanda Bernardes Google Scholar
Santos Junior, Dario Autor UNIFESP Google Scholar
Rodrigues, Consuelo Junqueira Google Scholar
Krug, Francisco Jose Google Scholar
Marumo, Julio Takehiro Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Bellini, Maria Helena Autor UNIFESP Google Scholar
Institution IPEN CNEN SP
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The development of cancer is a complex, multistage process during which a normal cell undergoes genetic changes that result in phenotypic alterations and in the acquisition of the ability to invade other sites. Inductively coupled plasma optical emission spectroscopy was used to estimate the contents of Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, P, Pb, and Zn in healthy kidney and renal cell carcinoma (RCC), and significant differences were found for all elements. Along with the progression of the malignant disease, a progressive decrease of Cd and K was observed. in fact, for Cd, the concentration in stage T4 was 263.9 times lower than in stage T1, and for K, the concentration in stage T4 was 1.73 times lower than in stage T1. Progressive accumulation was detected for P, Pb, and Zn in stage T4. for P, the concentration in stage T4 was 11.1 times higher than in stage T1; for Pb, the concentration in stage T4 was 232.7 times higher than in T1; and for Zn, the concentration in T4 was 8.452 times higher than in T1. This study highlights the marked differences in the concentrations of selected trace metals in different malignant tumor stages. These findings indicate that some trace metals may play important roles in the pathogenesis of RCC.
Keywords Trace elements
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/54253-6
CNPq: 133996/2008
Date 2009-08-01
Published in Biological Trace Element Research. Totowa: Humana Press Inc, v. 130, n. 2, p. 107-113, 2009.
ISSN 0163-4984 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 107-113
Access rights Closed access
Type Article
Web of Science ID WOS:000267102300002

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