Predictable variables for short- and long-term botulinum toxin treatment response in patients with cervical dystonia

Predictable variables for short- and long-term botulinum toxin treatment response in patients with cervical dystonia

Author Felicio, Andre C. Autor UNIFESP Google Scholar
Godeiro-Junior, Clecio Autor UNIFESP Google Scholar
Aguiar, Patricia de Carvalho Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Silva, Sonia M. A. Autor UNIFESP Google Scholar
Ferraz, Henrique B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We retrospectively evaluated 118 patients with cervical dystonia (CD) treated with botulinum toxin type A (BTX-A) for the following variables: gender, age at evaluation, age at symptom onset, disease duration, presence of head/neck pain and/or tremor, pattern of head deviation, disease progression (spreading of symptoms), etiology (primary vs. secondary), pretreatment with oral medication, and Tsui score. We investigated whether these parameters could predict the clinical outcome in a short- (< 30 days) and long-term basis. On short-term treatment, there were no clinically significant differences between BTX-A responsive and non-responsive patients. On long-term treatment, however, intake of oral medication previously to BTX-A injection and higher Tsui scores were predictors of favorable response. These results suggest that the greater CD severity the more likely patients will respond to BTX-A.
Keywords Cervical dystonia
Botulinum toxin type A
Tsui scale score
Treatment response
Language English
Date 2009-08-01
Published in Neurological Sciences. New York: Springer, v. 30, n. 4, p. 291-294, 2009.
ISSN 1590-1874 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 291-294
Origin http://dx.doi.org/10.1007/s10072-009-0097-8
Access rights Closed access
Type Article
Web of Science ID WOS:000267827700003
URI http://repositorio.unifesp.br/handle/11600/31705

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