Left Ventricle Radio-frequency Ablation in the Rat: A New Model of Heart Failure due to Myocardial Infarction Homogeneous in Size and Low in Mortality

Left Ventricle Radio-frequency Ablation in the Rat: A New Model of Heart Failure due to Myocardial Infarction Homogeneous in Size and Low in Mortality

Author Antonio, Ednei L. Autor UNIFESP Google Scholar
Dos Santos, Alexandra A. Autor UNIFESP Google Scholar
Araujo, Sergio R. R. Autor UNIFESP Google Scholar
Bocalini, Danilo S. Autor UNIFESP Google Scholar
Dos Santos, Leonardo Autor UNIFESP Google Scholar
Fenelon, Guilherme Autor UNIFESP Google Scholar
Franco, Marcelo F. Autor UNIFESP Google Scholar
Tucci, Paulo. J. F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the purpose of the Current study was to create a model of myocardial infarction (MI) that is homogeneous in size with a low immediate (24 hours) mortality.Methods and Results: Male and female rats (n = 256) underwent left ventricle (LV) ablation (Ab) by a radiofrequency current (1000 kHz; 12 watts for 12 seconds) to promote a MI. A transmural MI occurred in all rats. Post-Ab complex arrhythmias were frequent (atrioventricular block, ventricular tachycardia, and fibrillation), which rapidly and spontaneously reverted to sinus rhythm. Among 66 male rats, immediate mortality occurred in 7.5%. Small NIT size dispersion was characterized by smaller variability following Ab (x +/- SD: 45 +/- 8%) when compared with coronary occlusion (Oc; 40 +/- 19%). the histopathologic evaluations identified lesions similar to those which occurred following Oc, with scarring complete at 4 weeks. the hemodynamic and Doppler echocardiograms showed comparable increases in LV dimension, end-diastolic pressure, and pulmonary water content I and 4 weeks post-MI. Papillary muscle mechanics 6 weeks post-MI had matched inotropic and lusitropic dysfunction.Conclusions: LV Ab gave rise to a MI within a narrow size limit and with a low immediate mortality. LV Ab resulted in histopathologic evolution. ventricular dilation, and dysfunction, impairment in myocardial mechanics, and congestive outcome that reproduced a MI from Oc. (J Cardiac Fail 2009;15;540-548)
Keywords Rats
myocardial infarction
radiofrequency ablation
heart failure
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Universidade Federal de São Paulo
Date 2009-08-01
Published in Journal of Cardiac Failure. Philadelphia: Churchill Livingstone Inc Medical Publishers, v. 15, n. 6, p. 540-548, 2009.
ISSN 1071-9164 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone Inc Medical Publishers
Extent 540-548
Origin http://dx.doi.org/10.1016/j.cardfail.2009.01.007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000268897300011
URI http://repositorio.unifesp.br/handle/11600/31685

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