Rosewood oil induces sedation and inhibits compound action potential in rodents

Rosewood oil induces sedation and inhibits compound action potential in rodents

Author Almeida, Reinaldo Nobrega de Google Scholar
Machado Araujo, Demetrius Antonio Google Scholar
Ramos Goncalves, Juan Carlos Google Scholar
Montenegro, Fabricia Costa Google Scholar
Sousa, Damiao Pergentino de Google Scholar
Leite, Jose Roberto Autor UNIFESP Google Scholar
Mattei, Rita Autor UNIFESP Google Scholar
Venditti, Marco Antonio Campana Autor UNIFESP Google Scholar
Barbosa de Carvalho, Jose Gilberto Autor UNIFESP Google Scholar
Cruz, Jader Santos Google Scholar
Soares Maia, Jose Guilherme Google Scholar
Institution Universidade Federal de Minas Gerais (UFMG)
Universidade Federal da Paraíba (UFPB)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Pará (UFPA)
Abstract Aim of the study: Aniba rosaeodora is an aromatic plant which has been used in Brazil folk medicine due to its sedative effect. Therefore, the purpose of the present study was to evaluate the sedative effect of linalool-rich rosewood oil in mice. in addition we sought to investigate the linalool-rich oil effects on the isolated nerve using the single sucrose-gap technique.Materials and methods: Sedative effect was determined by measuring the potentiation of the pentobarbital-induced sleeping time. the compound action potential amplitude was evaluated as a way to detect changes in excitability of the isolated nerve.Results: the results showed that administration of rosewood oil at the doses of 200 and 300 mg/kg significantly decreased latency and increased the duration of sleeping time. On the other hand, the dose of 100 mg/kg potentiated significantly the pentobarbital action decreasing pentobarbital latency time and increasing pentobarbital sleeping time. in addition, the effect of linalool-rich rosewood oil on the isolated nerve of the rat was also investigated through the single sucrose-gap technique. the amplitude of the action potential decreased almost 100% when it was incubated for 30 min at 100 mu g/ml.Conclusions: From this study, it is suggested a sedative effect of linalool-rich rosewood oil that could, at least in part, be explained by the reduction in action potential amplitude that provokes a decrease in neuronal excitability. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Keywords Essential oil
Rosewood oil
Hypnotic action
Aniba rosaeodora
Compound action potential
Language English
Sponsor MCT/PPBio
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2009-07-30
Published in Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 124, n. 3, p. 440-443, 2009.
ISSN 0378-8741 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 440-443
Access rights Closed access
Type Article
Web of Science ID WOS:000269425900014

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