Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?

Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?

Author Calzavara, Mariana Bendlin Autor UNIFESP Google Scholar
Medrano, Wladimir Agostini Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Kameda, Sonia Regina Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Silva, Regina Helena Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Norte
Abstract Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). the aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the CFC performance after repeated exposure to the task were investigated. Pharmacological characterization consisted in the evaluation of the effects of the following drugs administered previously to the acquisition of the CFC: pentylenetetrazole (anxiogenic) and chlordiazepoxide (anxiolytic); methylphenidate and amphetamine (used for ADHD); lamotrigine, carbamazepine, and valproic acid (mood stabilizers); haloperidol, ziprasidone, risperidone, amisulpride, and clozapine (neuroleptic drugs); metoclopramide and SCH 23390 (dopamine antagonists without antipsychotic properties); and ketamine (a psychotomimmetic). the effects of paradoxical sleep deprivation (that worsens psychotic symptoms) and the performance in a latent inhibition protocol (an animal model of schizophrenia) were also verified. No differences in the sensitivity to the shock were observed. the repeated exposure to the CFC task did not modify the deficit in CFC presented by SHR. Considering pharmacological treatments, only the neuroleptic drugs reversed this deficit. This deficit was potentiated by proschizophrenia manipulations. Finally, a deficit in latent inhibition was also presented by SHR. These findings suggest that the deficit in CFC presented by SHR could be a useful animal model to study abnormalities in emotional context processing related to schizophrenia.
Keywords rats
psychiatric disorder
emotional memory
antipsychotics
amphetamine
mood stabilizers
Language English
Date 2009-07-01
Published in Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 35, n. 4, p. 748-759, 2009.
ISSN 0586-7614 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 748-759
Origin http://dx.doi.org/10.1093/schbul/sbn006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000268241700014
URI http://repositorio.unifesp.br/handle/11600/31613

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account