Risk factors for poor immune response to influenza vaccination in elderly people

Risk factors for poor immune response to influenza vaccination in elderly people

Author Bellei, Nancy Cristina Junqueira Autor UNIFESP Google Scholar
Carraro, Emerson Autor UNIFESP Google Scholar
Castelo Filho, Adauto Autor UNIFESP Google Scholar
Granato, Celso Francisco Hernandes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. Some studies have pointed out low immunogenicity in this group. Health status has been poorly investigated as a risk factor that may influence the immune response to influenza vaccine. We established an immunization response study of a highly-matched elderly population in a nursing home. One-hundred-twenty subjects of Ashkenazian origin had their vaccine-induced antibody response assessed. Good response was obtained in 30.8% (37/120), and 31.7% (38/120) did not react. A lack of good response was found to be associated with dementia (P=0.016) in a multivariate analysis. In addition to dementia, malnutrition was frequently observed among poor responders, suggesting that these factors should be considered in vaccination studies. Chemoprophylaxis in addition to vaccination for elderly presenting dementia should be considered, particularly for those people living nursing homes.
Keywords Influenza
vaccination
immune response
risk factors
dementia
Language English
Date 2006-08-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 269-273, 2006.
ISSN 1413-8670 (Sherpa/Romeo)
Publisher Brazilian Society of Infectious Diseases
Extent 269-273
Origin http://dx.doi.org/10.1590/S1413-86702006000400011
Access rights Open access Open Access
Type Article
SciELO ID S1413-86702006000400011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3158

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