A study of actinic cheilitis treatment by two low-morbidity CO(2) laser vaporization one-pass protocols

A study of actinic cheilitis treatment by two low-morbidity CO(2) laser vaporization one-pass protocols

Author Godoy Peres, Flavio Francisco de Autor UNIFESP Google Scholar
Haberbeck Brandao, Adriana Aigotti Google Scholar
Carvalho, Yasmin Rodarte Google Scholar
Doria Filho, Ulysses Google Scholar
Plapler, Helio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
São Paulo State Univ
Universidade de São Paulo (USP)
Abstract Therapeutic approaches to chronic actinic cheilitis focus on the removal or destruction of diseased epithelium. the CO(2) laser has become an important therapeutic alternative, achieving clinical resolution in around 90% of patients. Although many laser physical parameters have been reported, some are known for their low potential for scar induction without compromising the success of the results. the aim of this clinicohistological study was to compare the therapeutic responses to two low-morbidity protocols involving a single laser pass. A total of 40 patients with chronic multicentric and microscopically proven disease were randomly submitted to two conservative CO(2) laser protocols using a bilateral comparative model. the degree of histological atypia of the epithelium was determined in 26 patients both pre- and postoperatively for both protocols. Other histological phenomena were assessed in addition to this central analysis parameter. Clinical recurrence occurred in 12.5% of patients for each protocol, together with a significant reduction in the degree of epithelial atypia (p < 0.001), which was occasionally complete. However, no difference was found between the protocols (p > 0.05). Using these morphological parameters it was not possible to determine whether postoperative epithelial atypias in part of the sample were reactive or residual in nature. A few patients may show minor postoperative lesions. Due to their potential to achieve clinical and importantly microscopic resolution, the studied protocols may be used for mild through moderate dysplastic epithelium and clinically diffuse disease.
Keywords Actinic cheilitis
Oral precancer
Laser surgery
Oral epithelial dysplasia
Histopathology
Language English
Date 2009-05-01
Published in Lasers in Medical Science. Artington: Springer London Ltd, v. 24, n. 3, p. 375-385, 2009.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 375-385
Origin http://dx.doi.org/10.1007/s10103-008-0574-y
Access rights Closed access
Type Article
Web of Science ID WOS:000265499300012
URI http://repositorio.unifesp.br/handle/11600/31493

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