Analytical quantification of low-density lipoprotein using europium tetracycline indicator

Analytical quantification of low-density lipoprotein using europium tetracycline indicator

Author De Oliveira Silva, Flavia Rodrigues Autor UNIFESP Google Scholar
Monteiro, Andrea Moreira Google Scholar
Figueiredo Neto, Antonio M. Google Scholar
Gidlund, Magnus Google Scholar
Vieira Junior, Nilson Dias Google Scholar
Courrol, Lilia Coronato Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
IPEN CNEN SP
Abstract Low-density lipoprotein (LDL) is known as 'bad' cholesterol. If too much LDL circulates in the blood it can be retained in the walls of the arteries, causing atherosclerosis. in this paper we showed an alternative method to quantify LDL using the europium tetracycline (EuTc) indicator. the optical properties of the EuTc complex were investigated in aqueous solutions containing LDL. An enhancement was observed of the europium luminescence in the solutions with LDL compared those without the lipoprotein. A method to quantify the amount of LDL in a sample, based on EuTc enhanced luminescence, is proposed. the enhancement mechanism is also discussed. Copyright (C) 2009 John Wiley & Sons, Ltd.
Keywords low-density lipoprotein
europium
optical spectroscopy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
IMFCx (Instituto do Milenio de Fluidos Complexos)
Date 2009-05-01
Published in Luminescence. Chichester: John Wiley & Sons Ltd, v. 24, n. 3, p. 189-193, 2009.
ISSN 1522-7235 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 189-193
Origin http://dx.doi.org/10.1002/bio.1094
Access rights Closed access
Type Article
Web of Science ID WOS:000267637400010
URI http://repositorio.unifesp.br/handle/11600/31486

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