Does mobilization for autologous stem cell transplantation damage stromal layer formation?

Does mobilization for autologous stem cell transplantation damage stromal layer formation?

Author Schimieguel, Dulce Marta Autor UNIFESP Google Scholar
Dominato, Juliana Augusta Albieri Autor UNIFESP Google Scholar
Zattar, Karin Cecyn Autor UNIFESP Google Scholar
Regis Silva, Maria Regina Autor UNIFESP Google Scholar
Souza, Marlon Knabben de Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Borelli, Primavera Google Scholar
Rodrigues de Oliveira, Jose Salvador Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Autologous hematopoietic stem cell transplantation (HSCT) has proved efficient to treat hematological malignancies. However, some patients fail to mobilize HSCs. It is known that the microenvironment may undergo damage after allogeneic HSCT. However little is known about how chemotherapy and growth factors contribute to this damage. We studied the stromal layer formation(SLF) and velocity before and after HSC mobilization, through long-term bone marrow culture from 22 patients and 10 healthy donors. Patients' SLF was similar at pre- (12/22)and post-mobilization (9/20), however for controls this occurred more at pre- mobilization (9/10; p=0.03). SLF velocity was higher at pre than post-mobilization in both groups. Leukemias and multiple myeloma showed faster growth of SLF than lymphomas at post-mobilization, the latter being similar to controls. These findings could be explained by less uncommitted HSC in controls than patients at post-mobilization. Control HSCs may migrate more in response to mobilization, resulting in a reduced population by those cells.
Keywords Autologous stem cell transplantation
long-term bone marrow culture
mobilization
hematopoiesis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 02/0999-4
FAPESP: 02/010290-1
Date 2009-04-01
Published in Hematology. Leeds: Maney Publishing, v. 14, n. 2, p. 76-83, 2009.
ISSN 1024-5332 (Sherpa/Romeo, impact factor)
Publisher Maney Publishing
Extent 76-83
Origin http://dx.doi.org/10.1179/102453309X385232
Access rights Closed access
Type Article
Web of Science ID WOS:000268174700003
URI http://repositorio.unifesp.br/handle/11600/31449

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