Vascular Flow of the Gastric Fundus After Arterial Devascularization: An Experimental Study

Vascular Flow of the Gastric Fundus After Arterial Devascularization: An Experimental Study

Author Gomes, Marise Google Scholar
Ramacciotti, Eduardo Google Scholar
Miranda, Fausto Autor UNIFESP Google Scholar
Henriques, Alexandre Cruz Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Institution Jobst Vasc Ctr
Fifty Med Res
Universidade Federal de São Paulo (UNIFESP)
ABC Sch Med
Abstract Background. the main complication of transhiatal subtotal esophagectomy with esophagogastric reconstruction is anastomotic leak, which is responsible for a large number of postoperative deaths. It is believed that this complication is due to gastric fundus ischemia caused by the sectioning of the short gastric, left gastric, and left gastro-omental arteries. the literature, however, presents controversies. An experimental study was performed with the aim of evaluating the vascularization of the gastric fundus following sectioning of these arteries.Materials and methods. Forty mongrel dogs were distributed into 2 groups: a control group consisting of 15 dogs subjected to surgical simulation and an experimental group consisting of 25 dogs that underwent sectioning of these arteries. Fluorescein testing, gastric mummification, and morphometric image analysis were performed on both groups.Results. in comparison with the control group, fluorescein testing on the experimental group demonstrated time-delayed fluorescence in the gastric fundus and partial coloring, (P < 0.001). Image analysis on the mummified gastric samples demonstrated significant reduction in blood vessels in the gastric fundus of the experimental group (P < 0.001).Conclusions. We conclude that sectioning of the short gastric, left gastric, and left gastro-omental arteries causes reduction in blood circulation and in the quantity of blood vessels on the anterior side of the gastric fundus of dogs. (c) 2009 Elsevier Inc. All rights reserved.
Keywords gastric arteries
gastric fundus
arterial devascularization
experimental surgery
Language English
Date 2009-03-01
Published in Journal of Surgical Research. San Diego: Academic Press Inc Elsevier Science, v. 152, n. 1, p. 128-134, 2009.
ISSN 0022-4804 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 128-134
Origin http://dx.doi.org/10.1016/j.jss.2008.04.016
Access rights Closed access
Type Article
Web of Science ID WOS:000263245700017
URI http://repositorio.unifesp.br/handle/11600/31357

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