Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Author Corrêa, Silvana Aparecida Alves Autor UNIFESP Google Scholar
Noronha, Samuel Marcos Ribeiro de Google Scholar
Nogueira-de-Souza, Naiara Correa Google Scholar
Carvalho, Cristina Valleta de Google Scholar
Costa, Ana Maria Massad Google Scholar
Linhares, Jose Juvenal Google Scholar
Gomes, Mariano Tamura Vieira Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I (AT(1))-receptor A1166C polymorphisms.Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer.Results. the frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, chi(2) ); and for AT(1)-receptor were: AA, AC and CC (in %; cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, chi(2)). the results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls.Conclusions. the ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. the ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible targer for developing genetic markers for breast cancer.
Keywords angiotensin-converting enzyme
angiotensin II type 1 receptor
breast cancer
genotyping
polymorphisms
Language English
Date 2009-03-01
Published in Journal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 10, n. 1, p. 51-58, 2009.
ISSN 1470-3203 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 51-58
Origin http://dx.doi.org/10.1177/1470320309102317
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000265789800008
URI http://repositorio.unifesp.br/handle/11600/31337

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