Molecular Imaging Studies in Parkinson Disease Reducing Diagnostic Uncertainty

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dc.contributor.author Felicio, Andre Carvalho [UNIFESP]
dc.contributor.author Shih, Ming Chi [UNIFESP]
dc.contributor.author Godeiro-Junior, Clecio de Oliveira [UNIFESP]
dc.contributor.author Andrade, Luiz Augusto Franco de [UNIFESP]
dc.contributor.author Bressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.author Ferraz, Henrique Ballalai [UNIFESP]
dc.date.accessioned 2016-01-24T13:52:07Z
dc.date.available 2016-01-24T13:52:07Z
dc.date.issued 2009-01-01
dc.identifier http://dx.doi.org/10.1097/NRL.0b013e318183fdd8
dc.identifier.citation Neurologist. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 1, p. 6-16, 2009.
dc.identifier.issn 1074-7931
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31206
dc.description.abstract Background: the diagnosis of Parkinson disease (PD) is based on clinical criteria but misdiagnosis is as high as 25% of cases as confirmed by anatomic-pathologic studies. Since the introduction of in vivo molecular imaging techniques using Single-Photon Emission Computed Tomography and Positron Emission Tomography, the diagnosis of PD became more reliable by assessing dopaminergic and even nondopaminergic systems.Review Summary: the purpose of this article is to critically review the current data on molecular neuroimaging focusing on the nigrostriatal circuitry and providing useful information on the role of these new imaging techniques in the management of clinically unclear cases of PD.Conclusions: Patients with essential tremor, psychogenic Parkinsonism or drug-induced Parkinsonism can be differentiated from PD in doubtful situations using molecular imaging techniques evaluating striatal dopamine transporters (DAT). However, in patients with vascular Parkinsonism, atypical Parkinsonism and Parkinsonism associated with dementia DAT scans have less diagnostic usefulness. Scans with non-DAT tracers (ie, D2 dopamine receptors) are necessary together with long-term clinical follow-up, and rescans to improve diagnostic accuracy. en
dc.description.sponsorship Fondation Philanthropique Edmond J. Safra
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 6-16
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Neurologist
dc.rights Acesso restrito
dc.subject Parkinson disease en
dc.subject positron emission tomography en
dc.subject single-photon en
dc.subject emission computed tomography en
dc.subject PET en
dc.subject SPECT en
dc.subject diagnosis en
dc.title Molecular Imaging Studies in Parkinson Disease Reducing Diagnostic Uncertainty en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Israelita Albert Einstein
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Movement Disorders Unit, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Lab Interdiciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliation Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Movement Disorders Unit, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Lab Interdiciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.identifier.doi 10.1097/NRL.0b013e318183fdd8
dc.description.source Web of Science
dc.identifier.wos WOS:000262350000002



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