Molecular Imaging Studies in Parkinson Disease Reducing Diagnostic Uncertainty

Molecular Imaging Studies in Parkinson Disease Reducing Diagnostic Uncertainty

Author Felicio, Andre Carvalho Autor UNIFESP Google Scholar
Shih, Ming Chi Autor UNIFESP Google Scholar
Godeiro-Junior, Clecio de Oliveira Autor UNIFESP Google Scholar
Andrade, Luiz Augusto Franco de Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract Background: the diagnosis of Parkinson disease (PD) is based on clinical criteria but misdiagnosis is as high as 25% of cases as confirmed by anatomic-pathologic studies. Since the introduction of in vivo molecular imaging techniques using Single-Photon Emission Computed Tomography and Positron Emission Tomography, the diagnosis of PD became more reliable by assessing dopaminergic and even nondopaminergic systems.Review Summary: the purpose of this article is to critically review the current data on molecular neuroimaging focusing on the nigrostriatal circuitry and providing useful information on the role of these new imaging techniques in the management of clinically unclear cases of PD.Conclusions: Patients with essential tremor, psychogenic Parkinsonism or drug-induced Parkinsonism can be differentiated from PD in doubtful situations using molecular imaging techniques evaluating striatal dopamine transporters (DAT). However, in patients with vascular Parkinsonism, atypical Parkinsonism and Parkinsonism associated with dementia DAT scans have less diagnostic usefulness. Scans with non-DAT tracers (ie, D2 dopamine receptors) are necessary together with long-term clinical follow-up, and rescans to improve diagnostic accuracy.
Keywords Parkinson disease
positron emission tomography
single-photon
emission computed tomography
PET
SPECT
diagnosis
Language English
Sponsor Fondation Philanthropique Edmond J. Safra
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2009-01-01
Published in Neurologist. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 1, p. 6-16, 2009.
ISSN 1074-7931 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 6-16
Origin http://dx.doi.org/10.1097/NRL.0b013e318183fdd8
Access rights Closed access
Type Review
Web of Science ID WOS:000262350000002
URI http://repositorio.unifesp.br/handle/11600/31206

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