Novel Perspectives of Neural Stem Cell Differentiation: From Neurotransmitters to Therapeutics

Novel Perspectives of Neural Stem Cell Differentiation: From Neurotransmitters to Therapeutics

Author Trujillo, Cleber A. Google Scholar
Schwindt, Telma Tiemi Autor UNIFESP Google Scholar
Martins, Antonio Henrique Baccin Autor UNIFESP Google Scholar
Alves, Janaina Maria Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Araujo de Moraes Autor UNIFESP Google Scholar
Ulrich, Henning Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract In the past years, many reports have described the existence of neural progenitor and stem cells in the adult central nervous system capable of generating new neurons, astrocytes, and oligodendrocytes. This discovery has overturned the central assumption in the neuroscience field, of no new neurons being originated in the brain after birth and provided the fundaments to understand the molecular basis of neural differentiation and to develop new therapies for neural tissue repair. Although the mechanisms underlying cell fate during neural development are not yet understood, the importance of intrinsic and extrinsic factors and of an appropriate microenvironment is well known. in this context, emerging evidence strongly suggests that glial cells play a key role in controlling multiple steps of neurogenesis. Those cells, of particular radial glia, are important for migration, cell specification, and integration of neurons into a functional neural network. This review aims to present an update in the neurogenesis area and highlight the modulation of neural stem cell differentiation by neurotransmitters, growth factors, and their receptors, with possible applications for cell therapy strategies of neurological disorders. (C) 2008 international Society for Advancement of Cytometry
Keywords neural stem cells
neurogenesis
neurospheres
cell therapy
growth factors
neurotransmitters
Language English
Date 2009-01-01
Published in Cytometry Part A. Hoboken: Wiley-liss, v. 75A, n. 1, p. 38-53, 2009.
ISSN 1552-4922 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 38-53
Origin http://dx.doi.org/10.1002/cyto.a.20666
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000262061700005
URI http://repositorio.unifesp.br/handle/11600/31105

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