White matter spectroscopy in neuromyelitis optica A case control study

White matter spectroscopy in neuromyelitis optica A case control study

Author Bichuetti, Denis Bernardi Autor UNIFESP Google Scholar
Magalhaes Rivero, Rene Leandro Autor UNIFESP Google Scholar
Lobato de Oliveira, Enedina Maria Autor UNIFESP Google Scholar
Oliveira, Daniel May Autor UNIFESP Google Scholar
Souza, Nilton Amorin de Autor UNIFESP Google Scholar
Nogueira, Roberto Gomes Autor UNIFESP Google Scholar
Abdala, Nitamar Autor UNIFESP Google Scholar
Gabbai, Alberto Alain Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background Naa/Cr ratio in normal appearing white matter (NAWM) of patients with multiple sclerosis (MS) is altered beyond plaques, suggesting early axonal loss, and correlates to clinical disability. Brain lesions not typical of MS have been described in Neuromyelitis optica (NMO), and correspond to brain aquaporin-4 channel sites, but the evaluation of Naa/Cr ratio in NAWM of patients with NMO and its association to the presence of brain lesions and clinical disability have not been described. Objectives To evaluate the Naa/Cr of normal appearing white matter (NAWM) in 16 patients with NMO compared to healthy controls. Methods We performed brain magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of 16 patients with NMO and compared to age matched healthy controls. Results NAWM Naa/Cr did not show statistical difference among patients and controls, neither between patients that had normal brain MRI and atypical brain lesions. Conclusion NAWM was found to have a normal Naa/Cr in patients with NMO, reinforcing the concept that the white matter is not primarily affected in this disease.
Keywords white matter
spectroscopy
neuromyelitis optica
autoimmune disease
Language English
Date 2008-12-01
Published in Journal of Neurology. Heidelberg: Dr Dietrich Steinkopff Verlag, v. 255, n. 12, p. 1895-1899, 2008.
ISSN 0340-5354 (Sherpa/Romeo, impact factor)
Publisher Dr Dietrich Steinkopff Verlag
Extent 1895-1899
Origin http://dx.doi.org/10.1007/s00415-009-0940-0
Access rights Closed access
Type Article
Web of Science ID WOS:000263221100005
URI http://repositorio.unifesp.br/handle/11600/31062

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