Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis

Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis

Author Sato, Helio Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara C. Autor UNIFESP Google Scholar
D'Amora, Paulo Autor UNIFESP Google Scholar
Silva, Ismael D. C. G. Autor UNIFESP Google Scholar
Girao, Manoel J. B. C. Autor UNIFESP Google Scholar
Schor, Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate the association of intron 1 and exon 1 polymorphisms in the estrogen receptor a gene (ER-alpha) with endometriosis in women.Design: Association study.Setting: Endometriosis Unit, Federal University of São Paulo.Patient(s): the control group consisted of volunteers older than 45 years who had no evidence of endometriosis antecedents. Two groups with the disease were evaluated: the first group had stage I or 11 endometriosis and the second group stage III or IV.Intervention(s): Polymerase chain reaction (PCR) followed by digestion with HaeIII and MspI endonucleases (RFLP) were applied to detect intron I and exon I polymorphisms, respectively, in a total of 125 controls and 105 affected women.Main Outcome Measure(s): Frequency and distribution of HaeIII and MspI polymorphisms in ER-alpha.Result(s): No significant differences in the frequency of polymorphisms either in intron I or exon I of ER-alpha were found when endometriosis patients were compared with control subjects. Furthermore. the frequency of ER-a polymorphisms within the two different groups of patients with disease was statistically similar. the odds ratio between presence of intron I single-nucleotide polymorphisms (SNP) and endometriosis was 0.904, and the odds ratio between exon I SNP and endometriosis was 0.976.Conclusion(S): the evaluated polymorphisms were not associated with endometriosis. (Fertil Steril(R) 2008; 90:2086-90. (C) 2008 by American Society for Reproductive Medicine.)
Keywords Endometriosis/pathophysiology
endometriosis/genetics
estrogen receptor alpha/genetics
Language English
Date 2008-12-01
Published in Fertility and Sterility. New York: Elsevier B.V., v. 90, n. 6, p. 2086-2090, 2008.
ISSN 0015-0282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2086-2090
Origin http://dx.doi.org/10.1016/j.fertnstert.2007.10.023
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000261566800007
URI http://repositorio.unifesp.br/handle/11600/31048

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account