Asbestos-related Disease Progression of Parenchymal Abnormalities on High-resolution CT

Asbestos-related Disease Progression of Parenchymal Abnormalities on High-resolution CT

Author Silva, C. Isabela S. Google Scholar
Mueller, Nestor L. Google Scholar
Neder, J. Alberto Autor UNIFESP Google Scholar
Nogueira, Cristiano Rabelo Autor UNIFESP Google Scholar
Napolis, Lara Maris Autor UNIFESP Google Scholar
Terra-Filho, Mario Google Scholar
Bagatin, Ericson Google Scholar
Nery, Luiz E. Autor UNIFESP Google Scholar
Institution Univ British Columbia
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Jundiai Sch Med
Abstract Purpose: To evaluate the changes over time in the pattern and extent of parenchymal abnormalities in asbestos-exposed workers after cessation of exposure and to compare 3 proposed semiquantitative methods with a careful side-by-side comparison of the initial and the follow-Lip computed tomography (CT) images.Materials and Methods: the study included 52 male asbestos workers (mean age SD, 62.2y +/- 8.2) who had baseline high-resolution CT after cessation of exposure and follow-up CT 3 to 5 years later. Two independent thoracic radiologists quantified the findings according to the scoring systems proposed by Huuskonen, Gamsu, and Sette and then did a side-by-side comparison of the 2 sets of scans without awareness of the dates of the CT scans.Results: There was no difference in the prevalence of the 2 most common parenchymal abnormalities (centrilobular small dotlike or branching opacities and interstitial lines) between the initial and follow-up CT scans. Honeycombing (20%) and traction bronchiectasis and bronchiolectasis (50%) were seen more commonly on the follow-up CT than on the initial examination (10% and 33%, respectively) (P = 0.01). Increased extent of parenchymal abnormalities was evident on side-by-side comparison in 42 (81%) patients but resulted in an increase in score in at least 1 semiquantitative system in only 16 (31%) patients (all P > 0.01, signed test).Conclusions: the majority of patients with previous asbestos exposure show evidence of progression of disease on CT at 3 to 5 years follow-up but this progression is usually not detected by the 3 proposed semiquantitative scoring schemes.
Keywords asbestos
computed tomography
pleural plaques
Language English
Date 2008-11-01
Published in Journal of Thoracic Imaging. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 4, p. 251-257, 2008.
ISSN 0883-5993 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 251-257
Access rights Closed access
Type Article
Web of Science ID WOS:000261436600004

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