Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats

Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats

Author Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Patti, Camilla L. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Silva, Regina H. Google Scholar
Calzavara, Mariana B. Autor UNIFESP Google Scholar
Lopez, Giorgia B. Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Norte
Abstract The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PMDAT). which simultaneously evaluates learning. memory, anxiety and motor function. Four experiments were performed in which rats were submitted to: (1) post-training and pre-test PSD; (2) post-training or pre-test PSD: (3) pre-training PSD or pre-training paradoxical sleep (PS) rebound (24 h) and (4) pre-test PSD rebound. Concerning Experiment 1, post-training and pre-test PSD induced memory deficits, an anxiolytic-like behavior and an increase in locomotor activity. in Experiment II, both post-training PS-deprived and pre-test PS-deprived groups showed memory deficits per se. However, only the pre-test PS-deprived animals presented anxiolytic-like behavior and increased locomotor activity. in Experiment III, pre-training PS-deprived rats showed learning and memory deficits, anxiolytic-like behavior and increased locomotor activity. A 24 h-sleep recovery period after the PSD abolished the learning and memory deficits but not anxiety and locomotor alterations. Finally, sleep rebound did not modify acquisition (Experiment III) and retrieval (Experiment IV). This study strengthened the critical role of paradoxical sleep (but not sleep rebound) in all the phases of learning and memory formation. in addition, it suggests that PSD effects on acquisition and consolidation do not seem to be related to other behavioral alterations induced by this procedure. (C) 2008 Elsevier Inc. All rights reserved.
Keywords Sleep
Paradoxical sleep deprivation
Locomotor activity
Rebound
Learning
Memory
Anxiety
Motor function
Rats
Language English
Sponsor Associacao Fundo de Incentivo A Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CEPID
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 06/58274-5
FAPESP: 06/14606-9
CEPID: 98/14303-3
Date 2008-11-01
Published in Neurobiology of Learning and Memory. San Diego: Academic Press Inc Elsevier Science, v. 90, n. 4, p. 624-632, 2008.
ISSN 1074-7427 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 624-632
Origin http://dx.doi.org/10.1016/j.nlm.2008.07.013
Access rights Closed access
Type Article
Web of Science ID WOS:000261231000006
URI http://repositorio.unifesp.br/handle/11600/31013

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