Impact of Prolonged Physical Training on the Pituitary Glucocorticoid Sensitivity Determined by Very Low Dose Intravenous Dexamethasone Suppression Test

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dc.contributor.author Silva, T. S.
dc.contributor.author Longui, C. A.
dc.contributor.author Faria, C. D. C.
dc.contributor.author Rocha, M. N.
dc.contributor.author Melo, M. R.
dc.contributor.author Faria, T. G.
dc.contributor.author Souza e Almeida, J. A. de
dc.contributor.author Hayashi, L. F. [UNIFESP]
dc.contributor.author Kater, C. E. [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:45Z
dc.date.available 2016-01-24T13:51:45Z
dc.date.issued 2008-10-01
dc.identifier http://dx.doi.org/10.1055/s-2008-1078727
dc.identifier.citation Hormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 40, n. 10, p. 718-721, 2008.
dc.identifier.issn 0018-5043
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30954
dc.description.abstract The activity of the hypothalamic-pituitary-adrenal axis is usually modulated by several stress factors, including exercise. Different responses are induced by physical training according to duration and intensity of exercise. During prolonged training, cortisol remains normal or decreased as a consequence of altered cortisol secretion, metabolism and excretion, and possibly by changes in glucocorticoid sensitivity. the aim of this study was to evaluate the impact of prolonged physical training on the glucocorticoid sensitivity. Eighteen cadets of the Air Force Academy, mean (SD) age: 18.7 (1.0) years, underwent an intensive 6-week preparatory training-period considered adequate by inducing significant changes on body composition measured by bioelectrical impedance. Measurement of individual's pituitary glucocorticoid sensitivity was done by an intravenous very low dose dexamethasone suppression test (20 mu g/m(2)) that was performed before and after the training period. Cortisol levels were obtained at basal condition and 120 minutes after the dexamethasone infusion. Basal cortisol showed a significant decrease after prolonged training. the percent cortisol suppression after dexamethasone tended to be lower after the training period. Overall, our data suggest that prolonged physical training is able to reduce glucocorticoid sensitivity, which can have a beneficial impact in chronic stress conditions. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 718-721
dc.language.iso eng
dc.publisher Georg Thieme Verlag Kg
dc.relation.ispartof Hormone and Metabolic Research
dc.rights Acesso restrito
dc.subject HPA axis en
dc.subject glucocorticoid action en
dc.subject bioelectrical impedance en
dc.subject exercise en
dc.subject negative feedback en
dc.title Impact of Prolonged Physical Training on the Pituitary Glucocorticoid Sensitivity Determined by Very Low Dose Intravenous Dexamethasone Suppression Test en
dc.type Artigo
dc.contributor.institution Santa Casa São Paulo Fac Med Sci
dc.contributor.institution Brazilian AF Acad Pirassununga
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Santa Casa São Paulo Fac Med Sci, Dept Physiol, Mol Med Lab, São Paulo, Brazil
dc.description.affiliation Brazilian AF Acad Pirassununga, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Lab Steroids, Div Endocrinol, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Lab Steroids, Div Endocrinol, Dept Med, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 04/03208-2
dc.identifier.doi 10.1055/s-2008-1078727
dc.description.source Web of Science
dc.identifier.wos WOS:000260221800011



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