The effects of testosterone on sleep and sleep-disordered breathing in men: Its bidirectional interaction with erectile function

The effects of testosterone on sleep and sleep-disordered breathing in men: Its bidirectional interaction with erectile function

Author Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract As a major androgen with a key rote in developing and maintaining mate sexual characteristics, testosterone exerts a broad range of actions regulating several systems throughout human life. This article reviews data on the role of sleep in modulating endocrine release, as well. as data on the effects of testosterone and androgen-replacement therapy on sleep architecture and breathing. This review also discusses the interaction of testosterone and sleep, with a particular emphasis on bilateral effects. Changes in nocturnal testosterone are sleep-related, with levels rising during sleep and failing on waking, whereas circadian effects are apparently marginal. Peak testosterone levels coincide with rapid-eye movement (REM) sleep onset. the decreasing sleep efficiency and numbers of REM sleep episodes with altered REM sleep latency observed in older men are associated with lower concentrations of circulating testosterone. the well-established mate preponderance of sleep apnea suggests that sex hormones are involved in the pathogenesis of this breathing disorder. in addition, androgens are most certainly key players in the central and peripheral modulation of erectile function. Among other effects, sleep curtailment has been shown to lead to reduced levels of circulating androgens in healthy men and mate rodents, and this highlights the biological significance of sleep homeostasis for endocrine regulation. (C) 2008 Elsevier B.V. All. rights reserved.
Keywords Testosterone
Sleep
Sleep apnea
Sleep deprivation
Sleep-related breathing disorders
Erection
Androgens
Male
Language English
Sponsor Associacdo Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14303-3
Date 2008-10-01
Published in Sleep Medicine Reviews. London: W B Saunders Co Ltd, v. 12, n. 5, p. 365-379, 2008.
ISSN 1087-0792 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 365-379
Origin http://dx.doi.org/10.1016/j.smrv.2007.12.003
Access rights Closed access
Type Review
Web of Science ID WOS:000260218000005
URI http://repositorio.unifesp.br/handle/11600/30952

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account