Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

Author Marques, Alexandre F. Google Scholar
Silva, Marcelo B. da Google Scholar
Juliano, Maria A. P. Autor UNIFESP Google Scholar
Munhoz, Julian E. Google Scholar
Travassos, Luiz R. Autor UNIFESP Google Scholar
Taborda, Carlos Pelleschi Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Paracoccidioidomycosis is a systemic granulomatous disease manifested in the acute/subacute or chronic forms. the anergic cases of the acute/subacute form are most severe, leading to death threatening conditions. Drug treatment is required to control the disease but the response in anergic patients is generally poor. A 15-mer peptide from the major diagnostic antigen gp43, named P10, induces a T-CD4(+) helper-1 immune response in mice of different haplotypes and protects against intratracheal challenge with virulent P. brasiliensis. Presently, P10 immunization and chemotherapy were associated in an attempt to improve antifungal treatment in Balb/c mice made anergic by adding dexamethasone to the drinking water. the combined drug/peptide treatment significantly reduced the lung CFUs in infected anergic mice, largely preserved lung alveolar structure and prevented fungal dissemination to liver and spleen. Results recommend that a P10-based vaccine should be associated to chemotherapy for improved treatment of paracoccidioidomycosis aiming especially at anergic cases. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords P. brasiliensis
Anergy
Dexamethasone
Chemotherapy
Immunization
P10
gp43
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/07588-2
FAPESP: 06/50634-2
CNPq: 470636/2007-6
Date 2008-10-01
Published in Microbes and Infection. Amsterdam: Elsevier B.V., v. 10, n. 12-13, p. 1251-1258, 2008.
ISSN 1286-4579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1251-1258
Origin http://dx.doi.org/10.1016/j.micinf.2008.07.027
Access rights Closed access
Type Article
Web of Science ID WOS:000261368400004
URI http://repositorio.unifesp.br/handle/11600/30943

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