Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

Author Blanco, Yara C. Google Scholar
Farias, Alessandro S. Google Scholar
Goelnitz, Uta Google Scholar
Lopes, Stefanie C. P. Google Scholar
Arrais-Silva, Wagner W. Google Scholar
Carvalho, Bruna O. Google Scholar
Amino, Rogerio Autor UNIFESP Google Scholar
Wunderlich, Gerhard Google Scholar
Santos, Leonilda M. B. Google Scholar
Giorgio, Selma Google Scholar
Costa, Fabio Trindade Maranhão Autor UNIFESP Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Cerebral malaria (CM) is a syndrome characterized by neurological signs, seizures and coma. Despite the fact that CM presents similarities with cerebral stroke, few studies have focused on new supportive therapies for the disease. Hyperbaric oxygen (HBO) therapy has been successfully used in patients with numerous brain disorders such as stroke, migraine and atherosclerosis.Methodology/Principal Findings: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) were exposed to daily doses of HBO (100% O(2), 3.0 ATA, 1-2 h per day) in conditions well-tolerated by humans and animals, before or after parasite establishment. Cumulative survival analyses demonstrated that HBO therapy protected 50% of PbA-infected mice and delayed CM-specific neurological signs when administrated after patent parasitemia. Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gamma delta and alpha beta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB)dysfunction and hypothermia.Conclusions/Significance: the data presented here is the first indication that HBO treatment could be used as supportive therapy, perhaps in association with neuroprotective drugs, to prevent CM clinical outcomes, including death.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2004/00638-6
Date 2008-09-04
Published in Plos One. San Francisco: Public Library Science, v. 3, n. 9, 10 p., 2008.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent 10
Origin http://dx.doi.org/10.1371/journal.pone.0003126
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000264419100001
URI http://repositorio.unifesp.br/handle/11600/30902

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