Immune-expression of HSP27 and IL-10 in recurrent aphthous ulceration

Immune-expression of HSP27 and IL-10 in recurrent aphthous ulceration

Author Miyamoto, Nelson T. Autor UNIFESP Google Scholar
Borra, Ricardo Carneiro Google Scholar
Abreu, Marilda Autor UNIFESP Google Scholar
Weckx, Luc Louis Maurice Autor UNIFESP Google Scholar
Franco, Marcello Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ibirapuera Univ UNIB
Abstract BACKGROUND: Recently, abnormal cellular immune response has been considered responsible for the oral lesion in the recurrent aphthous ulceration (RAU). for reasons not yet defined, antigens of the oral microbiota would trigger abnormal Th1 immune response against epithelial cells. On the other hand, studies have demonstrated that heat shock proteins (HSP) can block the production of proinflammatory cytokine through inhibition of NF-kappa B and mitogen-activated protein kinase pathways or activate anti-inflammatory cytokines and therefore control the magnitude of the immune response. HSP27 has been considered a powerful inductor of IL-10, a major inhibitor of Th1 response.METHODS: Using immunohistochemistry, we studied the expression and location of HSP27 and IL-10 in ulcerated lesions clinically diagnosed as RAU (n = 27) and to compare it with that of oral clinically normal mucosa (CT; n = 6) and of other inflammatory chronic diseases such as oral fibrous inflammatory hyperplasia (FIH; n = 18), Crohn's disease (CD; n = 10) and ulcerative colitis (UC; n = 9).RESULTS: A lower proportion of HSP27-positive epithelial cells in RAU and CD were observed when compared with CT and FIH (P < 0.001**; P = 0.013**). A lower proportion of IL-10-positive interstitial cells in RAU was observed when compared with FIH, UC, CT and CD (P < 0.001**; P < 0.001**; P < 0.001**; P = 0.034*).CONCLUSION: Altogether the data suggest that a reduced cellular expression of HSP27 and IL-10 in RAU might be related with the aetiopathogenesis of the ulcerated oral lesions.
Keywords heat shock protein 27
interleukin 10
recurrent aphthous ulceration
Language English
Date 2008-09-01
Published in Journal of Oral Pathology & Medicine. Malden: Wiley-Blackwell, v. 37, n. 8, p. 462-467, 2008.
ISSN 0904-2512 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 462-467
Access rights Closed access
Type Article
Web of Science ID WOS:000258219300003

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