Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism

Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism

Author Ozaki, K. S. Google Scholar
Marques, G. M. Google Scholar
Nogueira, E. Google Scholar
Feitoza, R. Q. Google Scholar
Cenedeze, M. A. Google Scholar
Franco, M. F. Autor UNIFESP Google Scholar
Mazzali, M. Google Scholar
Soares, M. P. Google Scholar
Pacheco-Silva, A. Google Scholar
Camara, N. O. S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Gulbenkian Inst Sci
Universidade de São Paulo (USP)
Abstract Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. the HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (< 27 repeats) and long repeats (L) (>= 27 repeats). A total of 47.5% of the donors carried the S allele. the allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. for the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.
Keywords graft survival
heme oxygenase-1
polymorphism
renal graft function
renal transplantation
Language English
Date 2008-09-01
Published in Clinical Transplantation. Malden: Wiley-Blackwell, v. 22, n. 5, p. 609-616, 2008.
ISSN 0902-0063 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 609-616
Origin http://dx.doi.org/10.1111/j.1399-0012.2008.00832.x
Access rights Closed access
Type Article
Web of Science ID WOS:000259341800013
URI http://repositorio.unifesp.br/handle/11600/30896

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