Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats

Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats

Author Campos, Jose Humberto O. Google Scholar
Gomes, Heitor Carvalho Autor UNIFESP Google Scholar
dos-Santos, Washington L. C. Google Scholar
Cardeal, Mauricio Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Escola Bahiana Med & Saude Publ
Universidade Federal de São Paulo (UNIFESP)
Fundacao Oswaldo Cruz
Abstract Background: Tobacco use is associated with a high incidence of skin necrosis after surgery. the ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. the aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats.Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and I week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the Surgery; Group VI: continuously injected with nicotine for 4 weeks before and I week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed I week after the surgery.Results: the necrotic area was smaller in group I (8.85 cm(2)) than in group II (12.15 cm(2)), III (12.88 cm(2)) and VI (14.84 cm(2)) (ANOVA p < 0.0001). There was no difference between groups I, IV (10.13 cm(2)) and V (9.27 cm(2)).Conclusions: in conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model. (C) 2008 Published by Elsevier GmbH.
Keywords nicotine
McFARLANE skin flaps
necrosis
tobacco
rats
Language English
Date 2008-09-01
Published in Experimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 60, n. 6, p. 449-452, 2008.
ISSN 0940-2993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 449-452
Origin http://dx.doi.org/10.1016/j.etp.2008.02.004
Access rights Closed access
Type Article
Web of Science ID WOS:000259659800004
URI http://repositorio.unifesp.br/handle/11600/30886

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