Clinical value of anthropometric estimates of leg lean volume in nutritionally depleted and non-depleted patients with chronic obstructive pulmonary disease

Clinical value of anthropometric estimates of leg lean volume in nutritionally depleted and non-depleted patients with chronic obstructive pulmonary disease

Author Villaca, Debora Strose Autor UNIFESP Google Scholar
Lerario, Maria Cristina Autor UNIFESP Google Scholar
dal Corso, Simone Autor UNIFESP Google Scholar
Napolis, Lara Autor UNIFESP Google Scholar
Pereira de Albuquerque, Andre Luiz Autor UNIFESP Google Scholar
Lazaretti-Castro, Marize Autor UNIFESP Google Scholar
Sachs, Anita Autor UNIFESP Google Scholar
Nery, Luiz Eduardo Autor UNIFESP Google Scholar
Neder, Jose Alberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study aimed to investigate the clinical usefulness of an anthropometrically based method for estimating leg lean volume (LLV) in patients with chronic obstructive pulmonary disease (COPD) who presented or not with nutritional depletion. We prospectively evaluated a group of forty-eight patients (thirty-eight males) with moderate to severe COPD (Global Initiative for Chronic Obstructive Lung disease stages II-IV) who underwent a 6 min walking test and knee isokinetic dynamometry. Leg lean mass (muscle mass plus bone) was determined by dual-energy X-ray absorptiometry (DEXA) with derivation of its respective volume: these values were compared with those obtained by the truncated cones method first described by Jones and Pearson in 1969. As expected, depleted patients (n 19) had reduced exercise capacity and impaired muscle performance as compared to non-depleted subjects (P<0.01). the mean bias of the LLV differences between anthropometry and DEXA were 0.40 litre (95 % CI - 0.59, 1.39) and 0.50 litre (95% CI - 1.08, 2.08) for depleted and non-depleted patients, respectively. Anthropometrically and DEXA-based estimates correlated similarly with muscle functional attributes. A ROC curve analysis revealed that leg height-corrected LLV values had acceptable sensitivity and specificity to identify depleted patients (area under the curve 0.93 (range 0.86-1.00); P<0.001). Moreover, patients with LLV <= 9.2 litres/m (the best cut-off value according to the ROC curve) had significantly lower exercise capacity and muscle performance than their counterparts (P<0.05). in conclusion. an anthropometrically based method of estimating LLV (Jones and Pearson method) was shown to present with clinically acceptable accuracy and external validity in depleted and non-depleted patients with stable COPD.
Keywords anthropometry
DEXA
chronic obstructive pulmonary disease
body composition
Language English
Date 2008-08-01
Published in British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 100, n. 2, p. 380-386, 2008.
ISSN 0007-1145 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 380-386
Origin http://dx.doi.org/10.1017/S0007114507886399
Access rights Closed access
Type Article
Web of Science ID WOS:000257952000020
URI http://repositorio.unifesp.br/handle/11600/30829

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