The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis

The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis

Author Arganaraz, Gustavo Adolfo Autor UNIFESP Google Scholar
Konno, Ana Carla Autor UNIFESP Google Scholar
Perosa, Sandra Regina Autor UNIFESP Google Scholar
Santiago, Joselita Ferreira Carvalho Autor UNIFESP Google Scholar
Boim, Mirian A. Autor UNIFESP Google Scholar
Vidotti, Daniela Berguio Autor UNIFESP Google Scholar
Varella, Pedro Paulo Vasconcellos Autor UNIFESP Google Scholar
Costa, Luciana Gilbert Autor UNIFESP Google Scholar
Canzian, Mauro Google Scholar
Porcionatto, Marimelia Aparecida Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Sakamoto, Americo Ceiki Autor UNIFESP Google Scholar
Carrete, Henrique Autor UNIFESP Google Scholar
Centeno, Ricardo Silva Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Silva, Jose Antonio Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Nove Julho Univ
Abstract Purpose: As reported by several authors, angiotensin II (AngII) is a proinflammatory molecule that stimulates the release of inflammatory cytokines and activates nuclear factor kappa B (NF kappa B), being also associated with the increase of cellular oxidative stress. Its production depends on the activity of the angiotensin converting enzyme (ACE) that hydrolyzes the inactive precursor angiotensin I (AngI) into AngII. It has been suggested that AngII underlies the physiopathological mechanisms of several brain disorders such as stroke, bipolar disorder, schizophrenia, and disease. the aim of the present work was to localize and quantify AngII AT1 and AT2 receptors in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis (MTS) submitted to corticoamygdalohippocampectomy for seizure control.Method: Immunohistochemistry, Western blot, and real-time PCR techniques were employed to analyze the expression of these receptors.Results: the results showed an upregulation of AngII AT1 receptor as well as its messenger ribonucleic acid (mRNA) expression in the cortex and hippocampus of patients with MTS. in addition, an increased immunoexpression of AngII AT2 receptors was found only in the hippocampus of these patients with no changes in its mRNA levels.Discussion: These data show, for the first time, changes in components of renin-angiotensin system (RAS) that could be implicated in the physiopathology of MTS.
Keywords angiotensin II AT1 and AT2 receptors
temporal lobe epilepsy
cortex
hippocampus
Language English
Date 2008-08-01
Published in Epilepsia. Oxford: Blackwell Publishing, v. 49, n. 8, p. 1348-1357, 2008.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 1348-1357
Origin http://dx.doi.org/10.1111/j.1528-1167.2008.01581.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000257988300008
URI http://repositorio.unifesp.br/handle/11600/30809

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