Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients

Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients

Author Carvalho Aguiar, Patricia de Autor UNIFESP Google Scholar
Lessa, Patricia Silva Autor UNIFESP Google Scholar
Godeiro Junior, Clecio Autor UNIFESP Google Scholar
Barsottini, Orlando Autor UNIFESP Google Scholar
Felicio, Andre Carvalho Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Azevedo Silva, Sonia Maria de Autor UNIFESP Google Scholar
Saba, Roberta Arb Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Moreira-Filho, Carlos A. Autor UNIFESP Google Scholar
Andrade, Luiz Augusto Franco de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Parkinson's disease (PD) etiology has been attributed both to genetic and environmental factors. in this study, we investigated Brazilian early-onset PD (EOPD) patients for mutations in PARK2 and PARK8, exposure to environmental factors and possible correlations between PARK2 polymorphisms, environmental exposure, and disease age of onset. We enrolled 72 EOPD index patients and 81 healthy volunteers. Both groups were investigated for environmental exposure. EOPD patients were screened for PARK2 and PARK8 mutations. PARK2 coding polymorphisms Ser167Asn and Va1380Leu were investigated in both groups. Mutations were present in 18% of the patients and in 32% of those with a positive family history. PARK2 mutations represented 12.5% and PARK8 mutations accounted for 5.5% of the mutations. A novel PARK2 mutation (D53X) was identified in 2 patients. A positive correlation was found between EOPD and well water drinking. in patients exposed to well water, a later age of onset was observed for those who carried at least one PARK2 380Leu allele. PARK2 mutations have an important role in EOPD Brazilian patients and PARK8 might be the second most important disease causing gene in this group. Well water drinking exposure represents a risk factor for EOPD and the PARK2 coding polymorphism Va1380Leu might be interacting with environmental factors acting as a disease modifier. (C) 2008 Movement Disorder Society.
Keywords Parkinson's disease
genetics
PARK2
PARK8
environment
polymorphism
Language English
Date 2008-07-15
Published in Movement Disorders. Hoboken: Wiley-liss, v. 23, n. 9, p. 1228-1233, 2008.
ISSN 0885-3185 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1228-1233
Origin http://dx.doi.org/10.1002/mds.22032
Access rights Closed access
Type Article
Web of Science ID WOS:000258421800005
URI http://repositorio.unifesp.br/handle/11600/30800

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