Chondroitin sulfate and kallikrein in saliva: Markers for glossodynia

Chondroitin sulfate and kallikrein in saliva: Markers for glossodynia

Author Loeb, L. M. Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, M. G. Autor UNIFESP Google Scholar
Porcionatto, M. A. Autor UNIFESP Google Scholar
Martins, J. R. M. Autor UNIFESP Google Scholar
Kouyoumdjian, M. Autor UNIFESP Google Scholar
Weckx, L. M. Autor UNIFESP Google Scholar
Nader, H. B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Glossodynia or burning mouth syndrome is a multifunctional disorder. the oral mucosa is apparently normal but patients report burning and dried mouth and painful tongue and lips. the present study reports biochemical and physiological markers in saliva of patients presenting glossodynia compared to normal subjects. Saliva-buffering capacity and contents of protein and hyaluronic (HA) acid were similar in both groups. in contrast, chondroitin sulfate (CS) concentration was decreased in the saliva of patients with glossodynia when compared to control group (p = 0.0036). On the other hand glandular kallikrein showed increased activity in the saliva of patients compared to normal subjects (p<0.0001). the data suggest involvement of the kinin system, possibly related to the low levels of CS. Depression could explain the low level of serotonin in patient serum (p=0.0478). (C) 2008 Elsevier B.V. All rights reserved.
Keywords hyaluronic acid
chondroitin sulfate
tissue kallikrein
bradykinin
Language English
Date 2008-07-01
Published in International Immunopharmacology. Amsterdam: Elsevier B.V., v. 8, n. 7, p. 1056-1058, 2008.
ISSN 1567-5769 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1056-1058
Origin http://dx.doi.org/10.1016/j.intimp.2008.03.002
Access rights Closed access
Type Article
Web of Science ID WOS:000256710500014
URI http://repositorio.unifesp.br/handle/11600/30761

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