Increase in bax expression and apoptosis are associated in Huntington's disease progression

Increase in bax expression and apoptosis are associated in Huntington's disease progression

Author Teles, A. V. F. F. Autor UNIFESP Google Scholar
Rosenstock, T. R. Autor UNIFESP Google Scholar
Okuno, C. S. Autor UNIFESP Google Scholar
Lopes, G. S. Autor UNIFESP Google Scholar
Bertoncini, C. R. A. Autor UNIFESP Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Huntington's disease (HD) is a hereditary dominant neurodegenerative disorder and the progression of the disease may be associated with apoptosis and altered expression of apoptotic proteins. the aim of this study was to investigate gene expression of bax and bcl-2 in tissues from R6/1 transgenic (TGN) mice of different ages (3, 6 and 9 months). the mRNA expression was investigated and related to apoptotic cells measured by TUNEL Results showed a significant and progressive increase in box levels in the cortex of TGN (from 10 to 33%) when compared to control (CT) (8 to 20%) mice with 3, 6 and 9-month-old. the increase in box was correlated with the elevation in the number of apoptotic nuclei, especially in the cortex of 6 (10%) and 9 (18%)-month-old mice. Increase in bax expression might be related to an apoptotic induction which contributes to the HD progression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Keywords bcl-2
bax
mRNA
apoptosis
aging
Huntington's disease
neurodegeneration
cell death
Language English
Date 2008-06-13
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 438, n. 1, p. 59-63, 2008.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 59-63
Origin http://dx.doi.org/10.1016/j.neulet.2008.03.062
Access rights Closed access
Type Article
Web of Science ID WOS:000257152000014
URI http://repositorio.unifesp.br/handle/11600/30730

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