IgE antibody responses in young children with atopic dermatitis

IgE antibody responses in young children with atopic dermatitis

Author Wahn, U. Google Scholar
Warner, J. Google Scholar
Simons, F. E. R. Google Scholar
Benedictis, F. M. de Google Scholar
Diepgen, T. L. Google Scholar
Naspitz, C. K. Autor UNIFESP Google Scholar
Longueville, M. de Google Scholar
Bauchau, V. Google Scholar
EPAAC Study Grp Google Scholar
Institution Univ London Imperial Coll Sci Technol & Med
Childrens Hosp
Salesi Childrens Hosp
Univ Heidelberg Hosp
Universidade Federal de São Paulo (UNIFESP)
UCB
Univ Kinder & Poliklin Klin Padiatrie Schwerpunkt
Abstract In 2184 young children aged 13-24 months with atopic dermatitis (SCORAD 5-59) serum IgE antibodies to a standard panel of food and inhalant allergens were assayed. the frequency of positive IgE responses (> 0.35 kU/l) increased with greater severity of skin disease. A significant minority of infants had levels of IgE antibody to foods to suggest they were at risk of acute reaction to those foods (7% to hen's egg, 3% to cow's milk, 4% to peanut). Our findings indicate that the frequency of positive IgE responses is related to disease severity and suggest that differences in the time course of the development of IgE responses to food, which are at maximum prevalence within the first year of life, while inhalant allergies, are still developing between 1 and 2 yr and beyond.
Keywords atopic dermatitis
IgE
sensitization
child
Language English
Date 2008-06-01
Published in Pediatric Allergy and Immunology. Malden: Wiley-Blackwell, v. 19, n. 4, p. 332-336, 2008.
ISSN 0905-6157 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 332-336
Origin http://dx.doi.org/10.1111/j.1399-3038.2007.00643.x
Access rights Closed access
Type Article
Web of Science ID WOS:000255835900008
URI http://repositorio.unifesp.br/handle/11600/30720

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