Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study

Corpus callosum in maltreated children with posttraumatic stress disorder: A diffusion tensor imaging study

Author Jackowski, Andrea P. Autor UNIFESP Google Scholar
Douglas-Palumberi, Heather Google Scholar
Jackowski, Marcel Google Scholar
Win, Lawrence Google Scholar
Schultz, Robert T. Google Scholar
Staib, Lawrence W. Google Scholar
Krystal, John H. Google Scholar
Kaufman, Joan Google Scholar
Institution Yale Univ
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum - the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to assess white matter integrity in the corpus callosum in 17 maltreated children with PTSD and 15 demographically matched normal controls. Children with PTSD had reduced fractional anisotropy in the medial and posterior corpus, a region which contains interhemispheric projections from brain structures involved in circuits that mediate the processing of emotional stimuli and various memory functions - core disturbances associated with a history of trauma. Further exploration of the effects of stress on the corpus callosum and white matter development appears a promising strategy to better understand the pathophysiology of PTSD in children. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords posttraumatic stress disorder
Language English
Date 2008-04-15
Published in Psychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 162, n. 3, p. 256-261, 2008.
ISSN 0925-4927 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 256-261
Access rights Closed access
Type Article
Web of Science ID WOS:000255122100009

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