Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview

Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview

Author Taborda, Carlos Pelleschi Autor UNIFESP Google Scholar
Silva, Marcelo Barbosa da Google Scholar
Nosanchuk, Joshua Daniel Google Scholar
Travassos, Luiz Rodolpho Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Albert Einstein Coll Med
Universidade Federal de São Paulo (UNIFESP)
Abstract Melanin pigments are substances produced by a broad variety of pathogenic microorganisms, including bacteria, fungi, and helminths. Microbes predominantly produce melanin pigment via tyrosinases, laccases, catecholases, and the polyketide synthase pathway. in fungi, melanin is deposited in the cell wall and cytoplasm, and melanin particles (ghosts) can be isolated from these fungi that have the same size and shape of the original cells. Melanin has been reported in several human pathogenic dimorphic fungi including Paracoccidioides brasiliensis, Sporothrix schenckii, Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides posadasii. Melanization appears to contribute to virulence by reducing the susceptibility of melanized fungi to host defense mechanisms and antifungal drugs.
Keywords Paracoccidioides brasiliensis
melanin
dimorphic fungi
susceptibility
pathogenesis
Language English
Date 2008-04-01
Published in Mycopathologia. Dordrecht: Springer, v. 165, n. 4-5, p. 331-339, 2008.
ISSN 0301-486X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 331-339
Origin http://dx.doi.org/10.1007/s11046-007-9061-4
Access rights Closed access
Type Article
Web of Science ID WOS:000255256100013
URI http://repositorio.unifesp.br/handle/11600/30555

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