Effects of lorazepam on visual perceptual abilities

Effects of lorazepam on visual perceptual abilities

Author Pompeia, S. Autor UNIFESP Google Scholar
Pradella-Hallinan, M. Autor UNIFESP Google Scholar
Manzano, G. M. Autor UNIFESP Google Scholar
Bueno, O. F. A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective To evaluate the effects of an acute dose of the benzodiazepine (BZ) lorazepam in young healthy volunteers on five distinguishable visual perception abilities determined by previous factor-analytic studies.Methods This was a double-blind, cross-over design study of acute oral doses of lorazepam (2 mg) and placebo in young healthy volunteers. We focused on a set of paper-and-pencil tests of visual perceptual abilities that load on five correlated but distinguishable factors (Spatial Visualization, Spatial Relations, Perceptual Speed, Closure Speed, and Closure Flexibility). Some other tests (DSST, immediate and delayed recall of prose; measures of subjective mood alterations) were used to control for the classic BZ-induced effects.Results Lorazepam impaired performance in the DSST and delayed recall of prose, increased subjective sedation and impaired tasks of all abilities except Spatial Visualization and Closure Speed. Only impairment in Perceptual Speed (Identical Pictures task) and delayed recall of prose were not explained by sedation.Conclusion Acute administration of lorazepam, in a dose that impaired episodic memory, selectively affected different visual perceptual abilities before and after controlling for sedation. Central executive demands and sedation did not account for results, so impairment in the Identical Pictures task may be attributed to lorazeparn's visual processing alterations. Copyright (c) 2008 John Wiley & Sons, Ltd.
Keywords lorazepam
visual abilities
central executive
working memory
Language English
Date 2008-04-01
Published in Human Psychopharmacology-clinical and Experimental. Chichester: John Wiley & Sons Ltd, v. 23, n. 3, p. 183-192, 2008.
ISSN 0885-6222 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 183-192
Origin http://dx.doi.org/10.1002/hup.927
Access rights Closed access
Type Article
Web of Science ID WOS:000255116100002
URI http://repositorio.unifesp.br/handle/11600/30546

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