Diphtheria, tetanus, and varicella immunity in health care workers in neonatal units

Diphtheria, tetanus, and varicella immunity in health care workers in neonatal units

Author Santos, Amelia Miyashiro Nunes dos Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Lobato, Renata Tonzar Autor UNIFESP Google Scholar
Prado, Seila Israel do Autor UNIFESP Google Scholar
Kopelman, Benjamin Israel Autor UNIFESP Google Scholar
Cavalcanti, Claudia Macapani Autor UNIFESP Google Scholar
Monomi, Mary Kazurne Ikezawa Autor UNIFESP Google Scholar
Weckx, Lily Yin Autor UNIFESP Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Susceptible health care workers are at risk of acquiring and transmitting vaccine-preventable diseases to or from patients. the objective of this study was to assess antibody levels against diphtheria, tetanus, and varicella in healthcare workers.Methods: Antibody levels against diphtheria, tetanus, and varicella were measured in health care professionals in 2 neonatal units at the Federal University of São Paulo, Brazil.Results: Between September and November 2002, 215 of 222 (96.8%) health care workers were studied. of those, 122 (56.7%) gave oral information regarding their vaccination status against diphtheria and tetanus and only 9 (4.2%) had their vaccination cards. Geometric mean antibody levels against diphtheria, tetanus, and varicella were 0.89 IU/mL (95%CI, 0.73 to 1.08), 0.86 IU/mL (95%CI, 0.68 to 1.07) and 1.10 IU/mL (95%CI, 0.98 to 1.24), respectively Using internationally accepted definitions, 200 (93.0%) and 182 (84.7%) individuals had full protection against diphtheria and tetanus, respectively. Regarding varicella, 213 (99.1%) individuals were immune and 2 (0.9%) had equivocal immunity against varicella. of 65 (30.2%) individuals without previous history of the illness, 63 (96.9%) were immune against varicella zoster virus.Conclusions: Based on serologic screening, most professionals were immune to diphtheria, tetanus, and varicella. Absence of previous history of varicella was an unreliable identifier of susceptibility to varicella zoster virus in the health care workers studied.
Language English
Date 2008-03-01
Published in American Journal of Infection Control. New York: Mosby-Elsevier, v. 36, n. 2, p. 142-147, 2008.
ISSN 0196-6553 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 142-147
Origin http://dx.doi.org/10.1016/j.ajic.2007.04.283
Access rights Closed access
Type Article
Web of Science ID WOS:000253677900011
URI http://repositorio.unifesp.br/handle/11600/30497

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