Relationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis

Relationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis

Author Setta, Jose Henrique Autor UNIFESP Google Scholar
Neder, Jose Alberto Autor UNIFESP Google Scholar
Bagatin, Ericson Google Scholar
Terra-Filho, Mario Google Scholar
Napolis, Lara Maris Autor UNIFESP Google Scholar
Dal Corso, Simone Autor UNIFESP Google Scholar
Amorin, Maria Marta Ferreira Autor UNIFESP Google Scholar
Rodrigues, Reynaldo Tavares Autor UNIFESP Google Scholar
Fernandes, Ana Luisa Godoy Autor UNIFESP Google Scholar
Nery, Luiz Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Med Sch Jundiai
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Ctr Univ Nove Julho
Abstract Background Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression in these patients.Methods Thirty-nine ex-workers with asbestosis on high-resolution CT (HRCT) and 21 non-exposed controls were evaluated. Sputum cytology and IL-8 in serum and sputum were related to lung function impairment.Results Subjects with asbestosis had reduced sputum cellularity but higher macrophagel neutrophil ratio and % macrophage as compared with controls. Sputum and serum IL-8 were also higher in patients with asbestosis (P < 0.05). in addition, evidence of lung architectural distorption on HRCT was associated with increased levels of serum IL-8. Interestingly, absolute macrophage number was negatively correlated with total lung capacity (r = -0.40; P = 0.04) and serum IL-8 to lung diffiusing capacity (r = -0.45; P = 0.01).Conclusions Occupationally exposed subjects with asbestosis on HRCT have cytologic abnormalities in induced sputum and increased local and systemic pro-inflammatory status which are correlated to functional impairment.
Keywords asbestosis
inflammation
pulmonary function
induced sputum
cytokines
Language English
Date 2008-03-01
Published in American Journal of Industrial Medicine. Hoboken: Wiley-liss, v. 51, n. 3, p. 186-194, 2008.
ISSN 0271-3586 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 186-194
Origin http://dx.doi.org/10.1002/ajim.20546
Access rights Closed access
Type Article
Web of Science ID WOS:000253221200004
URI http://repositorio.unifesp.br/handle/11600/30477

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