Donepezil improves obstructive sleep apnea in Alzheimer disease - A double-blind, placebo-controlled study

Donepezil improves obstructive sleep apnea in Alzheimer disease - A double-blind, placebo-controlled study

Author Moraes, Walter Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Sukys-Claudino, Lucia Autor UNIFESP Google Scholar
Guilleininault, Christian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract Background: There is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease.Methods: Randomized, double-blind, placebo-controlled design. Twenty-three patients with mild-to-moderate Alzheimer disease and apnea-hypopnea index (AHI) > 5/h were allocated to two groups: donepezil treated (n = 11) and placebo treated (n = 12). Polysomnography and cognitive evaluation using Alzheimer disease assessment scale-cognitive (ADAS-cog) subscale were performed at baseline and after 3 months. Cognitive and sleep data were analyzed using analysis of variance.Results: AHI and oxygen saturation improved significantly after donepezil treatment compared to baseline and placebo (p < 0.05). Rapid eye movement (REM) sleep duration increased after donepezil treatment (p < 0.05). ADAS-cog scores improved after donepezil treatment, although they did not correlate with REM sleep increase and sleep apnea improvement (p < 0.01).Conclusions: Donepezil treatment improved AHI and oxygen saturation in patients with Alzheimer disease. Treatment also increased REM sleep duration and reduced ADAS-cog scores. Trial registration: ClinicalTrials.gov Identifier: NCT00480870.
Keywords Alzheimer
donepezil
oxygen saturation
polysomnography
rapid eye movement sleep
sleep apnea
Language English
Date 2008-03-01
Published in Chest. Northbrook: Amer Coll Chest Physicians, v. 133, n. 3, p. 677-683, 2008.
ISSN 0012-3692 (Sherpa/Romeo, impact factor)
Publisher Amer Coll Chest Physicians
Extent 677-683
Origin http://dx.doi.org/10.1378/chest.07-1446
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000253933300016
URI http://repositorio.unifesp.br/handle/11600/30468

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