Identification of new splice variants of the genes GAFF and BCMA

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dc.contributor.author Smirnova, Anna S. [UNIFESP]
dc.contributor.author Andrade-Oliveira, Vinicius [UNIFESP]
dc.contributor.author Gerbase-DeLima, Maria [UNIFESP]
dc.date.accessioned 2016-01-24T13:49:33Z
dc.date.available 2016-01-24T13:49:33Z
dc.date.issued 2008-02-01
dc.identifier http://dx.doi.org/10.1016/j.molimm.2007.07.028
dc.identifier.citation Molecular Immunology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 4, p. 1179-1183, 2008.
dc.identifier.issn 0161-5890
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30428
dc.description.abstract The TNF superfamily ligands BAFF and APRIL and receptors BCMA, TACT and BAFF-R play an important role in the regulation of B cell immunity. A number of functionally important splice isoforms have already been characterized for these molecules, stimulating the search for new transcript variants (TVs). Here we report two new BAFF TVs and three BCMA TVs, all potentially codifying new proteins. BAFF TVs were expressed in peripheral blood mononuclear cells (PBMC) of nearly all the individuals studied, decreasing in level when PBMC were activated by PMA and ionomycin. They were also detected in PBMC cytoplasmic RNA. Low levels of the BAFF TVs in all lymphocyte subpopulations analyzed suggest that their main source in PBMC are monocytes. BCMA TVs were observed only in some CD 19+ cell samples. Functional studies concerning interaction between isoforms of BAFF, APRIL and their receptors are needed for elucidation of their significance in the immune response. (c) 2007 Elsevier B.V. All rights reserved. en
dc.format.extent 1179-1183
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Molecular Immunology
dc.rights Acesso restrito
dc.subject BAFF en
dc.subject BCMA en
dc.subject TNF superfamily en
dc.subject alternative splicing en
dc.subject splice variants en
dc.title Identification of new splice variants of the genes GAFF and BCMA en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Inst Chem, Dept Biochem, BR-05508900 São Paulo, SP, Brazil
dc.description.affiliation UNIFESP EPM, Dept Pediat, Div Immunogenet, BR-04040031 São Paulo, SP, Brazil
dc.description.affiliationUnifesp UNIFESP EPM, Dept Pediat, Div Immunogenet, BR-04040031 São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.molimm.2007.07.028
dc.description.source Web of Science
dc.identifier.wos WOS:000252232400036



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