Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats

Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats

Author Santos, Edson L. Autor UNIFESP Google Scholar
Souza, Kely de Picoli Autor UNIFESP Google Scholar
Guimarães, Paola Bianchi Autor UNIFESP Google Scholar
Reis, Felipe Castellani Gomes Autor UNIFESP Google Scholar
Silva, Sylvia Maria Affonso Autor UNIFESP Google Scholar
Costa-Neto, Claudio M. Google Scholar
Luz, Jacqueline Autor UNIFESP Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Obesity is considered a worldwide public health problem showing an increased prevalence in developing countries, with urgent need for new and more efficient drugs and therapies. Enalapril, an angiotensin-I converting enzyme inhibitor (ACEi), is classically used in antihypertensive therapies, however, earlier publications have shown that this drug could also have significant impact on body weight in rats as well as in humans, besides reducing blood pressure. the effect of this drug in the white adipose tissue has been neglected for long time, even considering that most components of the renin-angiotensin and kallikrein-kinin system are expressed in this tissue. Furthermore, the adipose tissue is considered today as one of the most important sites for endocrine/inflammatory regulation of appetite and energy output and AngII has been linked to the metabolism in this tissue. Therefore, we analyzed the influence of chronic enalapril treatment in normotensive rats at earlier ages, evaluating body weight, energy homeostasis, lipid profile and serum levels of the hormones leptin and insulin, in the presence of a standard or a palatable hyperlipidic diet regimen for one month. Our results show that enalapril treatment is able to reduce body fat on both diets, without alteration in serum lipid profile. Furthermore, animals receiving enalapril showed reduction in food intake, leptin level and energy intake. in summary, these findings show for the first time that the ACEi enalapril reduces body fat in young normotensive rats and highlights a novel target to treat obesity and associated diseases. (c) 2007 Elsevier B.V. All rights reserved.
Keywords converting enzyme inhibitors
enalapril
adipose tissue
obesity
body weight
leptin
Language English
Date 2008-02-01
Published in International Immunopharmacology. Amsterdam: Elsevier B.V., v. 8, n. 2, p. 247-253, 2008.
ISSN 1567-5769 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 247-253
Origin http://dx.doi.org/10.1016/j.intimp.2007.07.021
Access rights Closed access
Type Article
Web of Science ID WOS:000253025700021
URI http://repositorio.unifesp.br/handle/11600/30418

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