Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents

Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents

Author Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Prado, Wagner Luiz do Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Lofrano-Prado, Mara Cristina Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Cristofalo, Dejaldo J. M. Autor UNIFESP Google Scholar
Lederman, Henrique Manoel Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background. Visceral adiposity is the major risk factor for paediatric nonalcoholic fatty liver disease. Aims. Determine the prevalence of nonalcoholic fatty liver disease according to the visceral fat quartile. Subjects. 181 obese adolescents including 113 girls (16.58 +/- 1.56 years) and 68 boys (16.87 +/- 1.62 years) were evaluated. Methods. the inclusion criteria were obesity and post-pubertal stage of Tanner. Visceral fat of obese adolescents was distributed in quartiles after ultrasound nonalcoholic fatty liver disease diagnosis. Results. Nonalcoholic fatty liver disease prevalence was 45.30%. It was observed that 62.07% and 76.47% of girls and boys with nonalcoholic fatty liver disease were found in the 4th quartile. in a multivariate logistic analysis it was observed that only visceral fat remained statistically significant, every I cm increase in visceral fat was associated with a 1.97 fold (95% CI 1.06-3.66) in boys and 2.08 fold (95% CI 1.38-3.13) in girls increased risk to develop nonalcoholic fatty liver disease. Indeed it was verified a positive correlation between visceral fat, body mass index, insulin levels, homeostasis model assessment insulin resistance index and steatosis degree. Conclusions. Our findings suggested that the expansion of visceral fat was a determinant factor to increase nonalcoholic fatty liver disease prevalence and the visceral fat measured by ultrasound might be a good predictor to identify risk for nonalcoholic fatty liver disease in obese adolescents. It was confirmed by a stronger correlation between visceral fat and body mass index. (c) 2007 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier B.V. All rights reserved.
Keywords Nonalcoholic fatty liver disease
Visceral fat
Language English
Date 2008-02-01
Published in Digestive and Liver Disease. Pisa: Pacini Editore, v. 40, n. 2, p. 132-139, 2008.
ISSN 1590-8658 (Sherpa/Romeo, impact factor)
Publisher Pacini Editore
Extent 132-139
Access rights Closed access
Type Article
Web of Science ID WOS:000253402800009

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