Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women

Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women

Author Vieira, Lucinda Coelho Esperança Autor UNIFESP Google Scholar
Gomes, Mariano Tamura Vieira Autor UNIFESP Google Scholar
Castro, Rodrigo de Aquino Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara Corrêa Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Girão, Manoel João Batista Castello Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background. Uterine leiomyoma is the most common pelvic tumor in women of reproductive age. It is well established that endogenous sex hormones are involved in disease pathogenesis, and polymorphisms in genes encoding enzymes which act in the metabolism of steroid hormones, such as that for cytochrome P450c17 enzyme (CYP17), may therefore play a role in fibroid genesis. Variations in this gene have been thought to influence the susceptibility to hormone-related diseases. A single nucleotide polymorphism (T -> C) [rs1042386] in promoter region of CYP17 may alter its transcription. the present study was conducted to investigate the association between this polymorphism and the presence of uterine leiomyoma in Brazilian women.Methods. Genotyping of CYP17 was performed in 121 uterine fibroid patients and 120 unaffected women, using polymerase chain reaction and restriction fragment-length polymorphism analysis.Results. No significant difference in the CYP17 genotype distribution was noted between cases and controls (p=0.165). Conclusion. These findings suggest that the CYP17 gene polymorphism studied is unlikely to be associated with risk for uterine leiomyoma in Brazilian women.
Keywords uterine leiomyoma
uterine fibroids
hormone metabolism
CYP17
polymorphism
single nucleotide polymorphism
Language English
Date 2008-01-01
Published in Gynecological Endocrinology. New York: Informa Healthcare, v. 24, n. 7, p. 373-377, 2008.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 373-377
Origin http://dx.doi.org/10.1080/09513590802131830
Access rights Closed access
Type Article
Web of Science ID WOS:000257791800005
URI http://repositorio.unifesp.br/handle/11600/30318

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