Differential expression of new LTA splice variants upon lymphocyte activation

Differential expression of new LTA splice variants upon lymphocyte activation

Author Smirnova, Anna S. Google Scholar
Ferreira-Silva, Katia C. Google Scholar
Mine, Karina L. Google Scholar
Andrade-Oliveira, Vinicius Google Scholar
Shulzhenko, Natalia Google Scholar
Gerbase-DeLima, Maria Google Scholar
Morgun, Andrey Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally important isoforms generated by alternative splicing but alternative splicing of LTA has never been studied. the known LTA protein is encoded by a transcript containing four exons. Here we report seven new LTA splice variants, three of them evolutionary conserved. We demonstrate their presence in cytoplasmic RNA suggesting that they could be translated into new LTA isoforms. We observed that their expression is differentially regulated upon activation of peripheral blood mononuclear cells and lymphocyte subpopulations (CD4+, CD8+, and CD19+). Our data suggest that the new LTA splice variants might play a role in the regulation of the immune response. (C) 2007 Elsevier B.V. All rights reserved.
Keywords lymphotoxin alpha
alternative splicing
splice variants
lymphocyte activation
evolutionary conservation
Language English
Date 2008-01-01
Published in Molecular Immunology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 1, p. 295-300, 2008.
ISSN 0161-5890 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 295-300
Origin http://dx.doi.org/10.1016/j.molimm.2007.04.012
Access rights Closed access
Type Article
Web of Science ID WOS:000250013600035
URI http://repositorio.unifesp.br/handle/11600/30289

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