Hibernating mammals in sudden cardiac death in epilepsy: What do they tell us?

Hibernating mammals in sudden cardiac death in epilepsy: What do they tell us?

Author Colugnati, Diego Basile Autor UNIFESP Google Scholar
Arida, Ricardo M. Autor UNIFESP Google Scholar
Cravo, Sergio L. Autor UNIFESP Google Scholar
Schoorlemmer, Gerhardus Hermanus Maria Autor UNIFESP Google Scholar
Almeida, Antonio-Carlos Guimaraes de Google Scholar
Cavalheiro, Esper a. Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fedao Joao Del Rei
Abstract Epilepsy is the most common neurological disorder; approximately 1% of the population worldwide have epilepsy. Moreover, sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency and AED number. Additionally, the cause of SUDEP is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities during and between seizures. Very recently, our research group was the first to annunciate that winter temperatures may lead a cardiac abnormalities and hence sudden death, become a new potential risk factor to SUDEP. Quite interesting, several mammalian species have evolved to develop a physiological phenomenon called hibernation as a strategy for survival under adverse cold conditions. From cardiovascular point of view, it has been established that hibernating mammals inherited a stable cardiovascular function as a result of adaptation to extreme external and internal environments during hibernation. for instance, hibernating mammals show resistance to hypothermia at a cellular level, the membrane potentials and excitability are more stable in the cardiac cells of these animals (action potentials (60 mV) have been recorded in hibernators myocardium at -5 degrees C), the aortic smooth muscle cells from hibernators are able to maintain ionic gradients upon prolonged exposure to low temperatures, and cardiac myocytes from hibernating mammals maintain constant levels of intracellular free calcium and forceful contractility at 10 degrees C or lower. Taken together, in this paper we postulate that hibernators have some cardiovascular particularities that confer heart protection that could positively influence the cardiovascular system of patients with epilepsy. (C) 2007 Elsevier B.V. All rights reserved.
Language English
Date 2008-01-01
Published in Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 70, n. 5, p. 929-932, 2008.
ISSN 0306-9877 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 929-932
Origin http://dx.doi.org/10.1016/j.mehy.2007.10.005
Access rights Closed access
Type Article
Web of Science ID WOS:000255450800005
URI http://repositorio.unifesp.br/handle/11600/30288

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