Cell death and regeneration in the midgut of the mosquito, Culex quinquefasciatus

Cell death and regeneration in the midgut of the mosquito, Culex quinquefasciatus

Author Okuda, Kendi Google Scholar
Almeida, Fabio de Google Scholar
Mortara, Renato A. Google Scholar
Krieger, Henrique Google Scholar
Marinotti, Osvaldo Google Scholar
Bijovsky, A. Tania Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Calif Irvine
Abstract Haematophagy, the utilization of blood as food, has evolved independently among insects such as mosquitoes, bedbugs, fleas, and others. Accordingly, several distinct biological adaptations have occurred in order to facilitate the finding, ingestion and digestion of blood from vertebrate sources. Although blood meals are essential for survival and reproduction of these insects, mechanical and chemical stresses are caused by the ingestion of a sizable meal (frequently twice or more times the weight of the insect) containing large amounts of cytotoxic molecules such as haem. Here we present data showing that the stresses caused by a blood meal induce cell death in the midgut epithelium of Culex quinquefasciatus mosquitoes. the process involves apoptosis, ejection of dead cells to the midgut lumen and differentiation of basal regenerative cells to replace the lost digestive cells. the basal cell differentiation in blood-fed mosquito midguts represents an additional mechanism by which insects cope with the stresses caused by blood meals. C quinquefasciatus adult females are unable to replace lost cells following a third or fourth blood meal, which may have a significant impact on mosquito longevity, reproduction and vectorial capacity. (c) 2007 Elsevier B.V. All rights reserved.
Keywords Culex quinquefusciatus
mosquito
midgut
apoptosis
cell death
regenerative cell
cell differentiation
ultrastructure
Language English
Date 2007-12-01
Published in Journal of Insect Physiology. Oxford: Pergamon-Elsevier B.V., v. 53, n. 12, p. 1307-1315, 2007.
ISSN 0022-1910 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1307-1315
Origin http://dx.doi.org/10.1016/j.jinsphys.2007.07.005
Access rights Closed access
Type Article
Web of Science ID WOS:000251333200012
URI http://repositorio.unifesp.br/handle/11600/30186

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