Effects of estrogen and estrogen-progestogen therapy on homocysteine levels and their correlation with carotid vascular resistance

Effects of estrogen and estrogen-progestogen therapy on homocysteine levels and their correlation with carotid vascular resistance

Author Machado, Rogerio Bonassi Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Fernandes, Cesar Eduardo Autor UNIFESP Google Scholar
Lakryc, Eli Marcelo Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Institution Fac Med Jundiai
Universidade Federal de São Paulo (UNIFESP)
ABC Med Sch
Abstract Objective. To evaluate the correlation between homocysteine levels and carotid vascular resistance in menopausal women submitted to estrogen and estrogen-progestogen therapy.Methods. Eighty-six women with a mean age of 52 years were enrolled in a prospective, randomized, double-blind, 6-month study. Patients were allocated to use one of three oral therapies: placebo (n = 26), micronized estradiol 2 mg/day (n = 30) or micronized estradiol 2 mg/day plus norethisterone acetate 1 mg/day (n = 30). Evaluation of homocysteine levels and Doppler sonography of the common carotid artery, used to calculate pulsatility index (PI), were carried out prior to initiating therapy and at the end of the study. the correlation between these two parameters was evaluated using Pearson's coefficient of correlation.Results. There was a significant reduction in homocysteine levels in the groups treated with estrogen alone or estrogen combined with norethisterone. PI was significantly lower only in users of estrogen alone; however, no significant correlation was found between homocysteine measurements and PI.Conclusion. No significant correlation was found between homocysteine levels and carotid vascular resistance following hormone therapy.
Keywords homocysteine
hormone therapy
estrogens
vascular resistance
menopause
Language English
Date 2007-11-01
Published in Gynecological Endocrinology. Abingdon: Informa Healthcare-taylor & Francis, v. 23, n. 11, p. 619-624, 2007.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare-taylor & Francis
Extent 619-624
Origin http://dx.doi.org/10.1080/09513590701581663
Access rights Closed access
Type Article
Web of Science ID WOS:000251732500002
URI http://repositorio.unifesp.br/handle/11600/30138

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